调节性T细胞活性而非传统的HIV特异性T细胞反应与预防HIV-1感染相关。
Regulatory T-Cell Activity But Not Conventional HIV-Specific T-Cell Responses Are Associated With Protection From HIV-1 Infection.
作者信息
Pattacini Laura, Baeten Jared M, Thomas Katherine K, Fluharty Tayler R, Murnane Pamela M, Donnell Deborah, Bukusi Elizabeth, Ronald Allan, Mugo Nelly, Lingappa Jairam R, Celum Connie, McElrath M Juliana, Lund Jennifer M
机构信息
*Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Departments of †Global Health; ‡Epidemiology; §Medicine, University of Washington, Seattle, WA; ‖Statistical Center for HIV-1/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ¶Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya; #Department of Obstetrics and Gynecology, University of Washington, Seattle, WA; **Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada; ††Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya; and ‡‡Department of Pediatrics, University of Washington, Seattle, WA.
出版信息
J Acquir Immune Defic Syndr. 2016 Jun 1;72(2):119-28. doi: 10.1097/QAI.0000000000000919.
OBJECTIVE
Two distinct hypotheses have been proposed for T-cell involvement in protection from HIV-1 acquisition. First, HIV-1-specific memory T-cell responses generated on HIV-1 exposure could mount an efficient response to HIV-1 and inhibit the establishment of an infection. Second, a lower level of immune activation could reduce the numbers of activated, HIV-1-susceptible CD4 T cells, thereby diminishing the likelihood of infection.
METHODS
To test these hypotheses, we conducted a prospective study among high-risk heterosexual men and women, and tested peripheral blood samples from individuals who subsequently acquired HIV-1 during follow-up (cases) and from a subset of those who remained HIV-1 uninfected (controls).
RESULTS
We found no difference in HIV-1-specific immune responses between cases and controls, but Treg frequency was higher in controls as compared with cases and was negatively associated with frequency of effector memory CD4 T cells.
CONCLUSIONS
Our findings support the hypothesis that low immune activation assists in protection from HIV-1 infection.
目的
关于T细胞参与预防HIV-1感染提出了两种不同的假说。其一，HIV-1暴露后产生的HIV-1特异性记忆T细胞反应可对HIV-1产生有效反应并抑制感染的建立。其二，较低水平的免疫激活可减少活化的、对HIV-1易感的CD4 T细胞数量，从而降低感染的可能性。
方法
为验证这些假说，我们在高危异性恋男性和女性中进行了一项前瞻性研究，并检测了随访期间随后感染HIV-1的个体（病例）以及一部分未感染HIV-1的个体（对照）的外周血样本。
结果
我们发现病例组和对照组之间的HIV-1特异性免疫反应没有差异，但与病例组相比，对照组的调节性T细胞频率更高，且与效应记忆CD4 T细胞频率呈负相关。
结论
我们的研究结果支持低免疫激活有助于预防HIV-1感染这一假说。
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