基于碲化镉/硫化镉量子点增强化学发光法的盐酸青藤碱痕量分析
Trace Analysis of Sinomenine Hydrochloride Using CdTe/CdS Quantum Dots-enhanced Chemiluminescence.
作者信息
Wu Kegang, Han Suqin
机构信息
School of Chemistry and Material Science, Shanxi Normal University.
出版信息
Anal Sci. 2015;31(12):1249-53. doi: 10.2116/analsci.31.1249.
A novel flow-injection chemiluminescence (FI-CL) method was described for the determination of sinomenine hydrochloride (SIN). The method was based on the inhibitory effect of SIN on the CL reaction of luminol and K3Fe(CN)6 in an alkaline solution, which was sensitized by CdTe/CdS quantum dots (QDs). Under the optimized conditions, the linear range for the determination of SIN was 1.0 × 10(-8) to 1.4 × 10(-6) mol/L. The detection limit was 7.5 × 10(-9) mol/L, and the relative standard deviation was 2.47% (n = 11). The current CL method was applied to determine SIN in pharmaceutical formulations and biological fluids with satisfactory results. The possible CL reaction mechanism was discussed briefly.
描述了一种用于测定盐酸青藤碱（SIN）的新型流动注射化学发光（FI-CL）方法。该方法基于青藤碱对碱性溶液中鲁米诺与K3Fe(CN)6的化学发光反应的抑制作用，此反应由CdTe/CdS量子点（QDs）增敏。在优化条件下，测定青藤碱的线性范围为1.0×10(-8)至1.4×10(-6) mol/L。检测限为7.5×10(-9) mol/L，相对标准偏差为2.47%（n = 11）。将该化学发光方法应用于药物制剂和生物流体中SIN的测定，结果令人满意。简要讨论了可能的化学发光反应机理。
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