Shi Jian, Cao Bei, Wang Xin-Wen, Aa Ji-Ye, Duan Jin-Ao, Zhu Xuan-Xuan, Wang Guang-Ji, Liu Chang-Xiao
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, China; Pharmacy Department, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China.
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, China.
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 15;1026:204-216. doi: 10.1016/j.jchromb.2015.10.014. Epub 2015 Nov 24.
Traditional Chinese herb medicines (TCHMs) have been used in the treatment of a variety of diseases for thousands of years in Asian countries. The active components of TCHMs usually exert combined synergistic therapeutic effects on multiple targets, but with less potential therapeutic effect based on routine indices than Western drugs. These complex effects make the assessment of the efficacy of TCHMs and the clarification of their underlying mechanisms very challenging, and therefore hinder their wider application and acceptance. Metabolomics is a crucial part of systems biology. It allows the quantitative measurement of large numbers of the low-molecular endogenous metabolites involved in metabolic pathways, and thus reflects the fundamental metabolism status of the body. Recently, dozens of metabolomic studies have been devoted to prove the efficacy/safety, explore the underlying mechanisms, and identify the potential biomarkers to access the action targets of TCHMs, with fruitful results. This article presents an overview of these studies, focusing on the progress made in exploring the pharmacology and toxicology of various herbal medicines.
在亚洲国家，传统中草药已被用于治疗各种疾病达数千年之久。中草药的活性成分通常对多个靶点发挥联合协同治疗作用，但基于常规指标，其潜在治疗效果比西药要小。这些复杂的作用使得评估中草药的疗效以及阐明其潜在机制极具挑战性，因此阻碍了它们的更广泛应用和接受。代谢组学是系统生物学的关键组成部分。它能够对参与代谢途径的大量低分子内源性代谢物进行定量测量，从而反映机体的基本代谢状态。最近，数十项代谢组学研究致力于证明中草药的疗效/安全性、探索其潜在机制以及识别潜在生物标志物以确定中草药的作用靶点，取得了丰硕成果。本文对这些研究进行了综述，重点关注在探索各种草药的药理学和毒理学方面所取得的进展。
