通过使用不同长度链的鸡尾酒式聚乙二醇化增强纳米颗粒的靶向识别。
Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths.
作者信息
Ishii Takehiko, Miyata Kanjiro, Anraku Yasutaka, Naito Mitsuru, Yi Yu, Jinbo Takao, Takae Seiji, Fukusato Yu, Hori Mao, Osada Kensuke, Kataoka Kazunori
机构信息
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Chem Commun (Camb). 2016 Jan 25;52(7):1517-9. doi: 10.1039/c5cc06661a.
Monodispersed gold nanoparticles (AuNPs) were simultaneously decorated with lactosylated and non-modified shorter poly(ethylene glycol)s (PEGs) to enhance their target recognition. The decoration with sufficiently shorter PEGs dramatically enhanced the multivalent binding ability of lactosylated AuNPs to the lectin-fixed surface, possibly due to the enhanced mobility of the ligands via the spacer effect generated by the shorter PEG chains.
将乳糖基化和未修饰的较短聚乙二醇（PEG）同时修饰到单分散金纳米颗粒（AuNP）上，以增强其靶向识别能力。用足够短的PEG进行修饰显著增强了乳糖基化AuNP与凝集素固定表面的多价结合能力，这可能是由于较短PEG链产生的间隔效应增强了配体的流动性。
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