From the Department of Neurology (B.B., T.V., J.W.) and the Institute of Neuroradiology (W.M.-F.), University Medical Centre of the Johannes Gutenberg University, Mainz; Edith-Stein Fachklinik (B.B.), Bad Bergzabern; the Department of Neurology and German Center for Vertigo and Balance Disorders-IFB (J.C., T.S., V.K., M.D.), Ludwig-Maximilians-University, Munich; and Munich Center for Systems Neurology (SyNergy) (M.D.), Germany.
Neurology. 2016 Jan 12;86(2):134-40. doi: 10.1212/WNL.0000000000002238. Epub 2015 Dec 11.
To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV).
We used modern statistical lesion behavior mapping on a sample of 37 stroke patients with isolated thalamic lesions to clarify which thalamic regions are involved in graviceptive otolith processing and whether there are distinct regions associated with contraversive or ipsiversive SVV deviation.
We found 2 distinct systems of graviceptive processing within the thalamus. Contraversive tilt of SVV was associated with lesions to the nuclei dorsomedialis, intralamellaris, centrales thalami, posterior thalami, ventrooralis internus, ventrointermedii, ventrocaudales and superior parts of the nuclei parafascicularis thalami. The regions associated with ipsiversive tilt of SVV were located in more inferior regions, involving structures such as the nuclei endymalis thalami, inferior parts of the nuclei parafascicularis thalami, and also small parts of the junction zone of the nuclei ruber tegmenti and brachium conjunctivum.
Our data indicate that there are 2 anatomically distinct graviceptive signal processing mechanisms within the vestibular network in humans that lead, when damaged, to a vestibular tone imbalance either to the contraversive or to the ipsiversive side.
确定是否存在与主观垂直视觉（SVV）测量的垂直感知的反向或同侧干扰相关的统计学上不同的丘脑区域。
我们使用现代统计损伤行为映射对 37 名孤立性丘脑病变的中风患者样本进行分析，以明确哪些丘脑区域参与重力性耳石处理，以及是否存在与反向或同侧 SVV 偏差相关的不同区域。
我们发现了丘脑内 2 个不同的重力处理系统。SVV 的反向倾斜与背内侧核、内板层核、中央核、后丘脑、腹侧口部内核、腹侧中间核、腹侧尾核和丘脑束旁核的上部损伤有关。与 SVV 的同侧倾斜相关的区域位于更下方的区域，涉及到丘脑内膜核、丘脑束旁核下部、红核被盖部和结合臂交界处的小部分。
我们的数据表明，在人类的前庭网络中存在 2 种解剖上不同的重力信号处理机制，当这些机制受损时，会导致前庭张力失衡，偏向于反向或同侧。
