Ku Sae-Kwang, Yang Eun-Ju, Kang Hyejin, Jung Byeongjin, Bae Jong-Sup
Department of Anatomy and Histology, College of Korean Medicine, Daegu Hanny University, Gyeongsan, 712-715, South Korea.
College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 702-701, Republic of Korea.
Arch Pharm Res. 2016 Feb;39(2):271-278. doi: 10.1007/s12272-015-0694-4. Epub 2015 Dec 10.
The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.
分泌型IIA组磷脂酶A2（sPLA2-IIA）的表达会因炎症性疾病的发展而增强。在本研究中，在脂多糖（LPS）刺激的人脐静脉内皮细胞和小鼠中诱导sPLA2-IIA表达，以评估多孔菌素的作用。多孔菌素是韩国可食用蘑菇多孔菌的主要成分，已知具有抗氧化和抗炎等生物活性。多孔菌素通过抑制胞质磷脂酶A2和细胞外信号调节激酶1/2的磷酸化，显著抑制LPS介导的sPLA2-IIA蛋白表达和活性。这些结果表明，多孔菌素可能在炎症性疾病中对sPLA2-IIA表达和活性的调节中发挥重要作用。
