Joint Graduate School of Veterinary Science, Gifu University, Gifu, Japan.
Animal Medical Center, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Open Vet J. 2024 Jul;14(7):1538-1552. doi: 10.5455/OVJ.2024.v14.i7.3. Epub 2024 Jul 31.
Prognostic factors in dogs with nasal tumors include several variables. However, factors that can measure prognosis have not yet been identified due to considerable divergence among reports.
To describe the computed tomography (CT) imaging, treatment, and outcomes of dogs with nasal tumors, as well as detect negative prognostic factors through the analysis of a substantial number of cases from a single institution. Furthermore, based on CT findings, this study aimed to identify independent prognostic factors for nasal tumors in dogs.
A total of 166 client-owned dogs were diagnosed with nasal tumors at Gifu University Veterinary Hospital between 2015 and 2019. Data were retrospectively collected from the electronic medical records.
Univariate analysis revealed a significant difference in survival time between adenocarcinoma and squamous cell carcinoma in 166 canine nasal tumors treated with megavoltage (MeV) radiation therapy at a single institution ( = .015). There was a significant difference in survival time between carcinoma and sarcoma ( = .04). Regarding CT imaging findings, significant differences in survival time were observed for frontal sinus invasion ( = .007), cribriform plate destruction ( < .001), and lymph node metastasis ( = .003). Multivariate Cox regression analysis was performed to assess frontal sinus invasion, cribriform plate destruction, histopathologic subtypes, and lymph node metastasis as negative prognostic factors; however, only cribriform plate destruction was a significant negative prognostic factor for survival time ( = .004).
Multivariate Cox regression analysis showed that cribriform plate destruction was the main factor in predicting a negative prognosis among 166 canine nasal tumors treated with MeV radiation therapy at a single institution. Therefore, we propose a new 2-tier staging classification for canine nasal tumors with the presence or absence of cribriform plate destruction based on CT examination as the only evaluation factor.
犬鼻腔肿瘤的预后因素包括多个变量。然而，由于报告之间存在较大差异，尚未确定可衡量预后的因素。
描述单机构大量病例中犬鼻腔肿瘤的计算机断层扫描（CT）成像、治疗和结果，并通过分析发现负性预后因素。此外，基于 CT 结果，本研究旨在确定犬鼻腔肿瘤的独立预后因素。
2015 年至 2019 年，在岐阜大学兽医医院诊断出 166 例患有鼻腔肿瘤的犬。从电子病历中回顾性收集数据。
单变量分析显示，在单机构接受兆伏（MeV）放射治疗的 166 例犬鼻腔肿瘤中，腺癌和鳞状细胞癌的生存时间有显著差异（ =.015）。癌和肉瘤的生存时间有显著差异（ =.04）。关于 CT 成像结果，额窦侵犯（ =.007）、筛板破坏（ <.001）和淋巴结转移（ =.003）的生存时间有显著差异。多变量 Cox 回归分析评估额窦侵犯、筛板破坏、组织病理学亚型和淋巴结转移作为负性预后因素；然而，只有筛板破坏是生存时间的显著负性预后因素（ =.004）。
多变量 Cox 回归分析显示，在单机构接受 MeV 放射治疗的 166 例犬鼻腔肿瘤中，筛板破坏是预测预后不良的主要因素。因此，我们提出了一种新的基于 CT 检查的犬鼻腔肿瘤 2 级分期分类，根据是否存在筛板破坏作为唯一评估因素。
