粗糙脉孢菌谷氨酰胺营养缺陷型的遗传学与生理学
Genetics and physiology of Neurospora crassa glutamine auxotrophs.
作者信息
Dávila G, Sánchez F, Palacios R, Mora J
出版信息
J Bacteriol. 1978 Jun;134(3):693-8. doi: 10.1128/jb.134.3.693-698.1978.
Abstract
This work reports on the isolation and characterization of two glutamine auxotrophs in Neurospora crassa. The mutations responsible for the glutamine-requiring phenotype were very closely linked, and one of them proved to be recessive to wild type. The mutations impaired the conversion of glutamic acid to glutamine and resulted in changes of both the activity and oligomeric structure of the enzyme glutamine synthetase.
摘要
这项工作报道了粗糙脉孢菌中两个谷氨酰胺营养缺陷型菌株的分离和特性。导致谷氨酰胺需求表型的突变紧密连锁，其中一个对野生型呈隐性。这些突变损害了谷氨酸向谷氨酰胺的转化，并导致谷氨酰胺合成酶的活性和寡聚结构发生变化。
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