Hosoi H, Asakura Y, Irie M, Hataya N, Tsunoda M, Ohki Y, Mineda T, Teshirogi T
Nihon Ika Daigaku Zasshi. 1989 Jun;56(3):241-4. doi: 10.1272/jnms1923.56.241.
Microalbuminuria in diabetics is considered to be a sensitive indicator of early diabetic nephropathy. In this paper, 24 h-urinary excretions of albumin, BMG and NAG activity were measured in forty-one children with insulin-dependent diabetes mellitus. Moreover, the relationships between the urinary excretions of these substances and various clinical parameters of diabetes were analyzed. The mean values (mean +/- SD) of 24 h-urinary albumin, BMG and NAG activity in the diabetic children were 8.0 +/- 10.6 mg/day, 61.2 +/- 69.0 micrograms/day and 1.87 +/- 1.30 U/day, respectively. No significant differences were found between diabetic children and normal controls for these mean values. Nor were significant correlations between the various clinical parameters of diabetes and the urinary excretions of any of these substances found. However, nine of the forty-one diabetic children (22.0%) had higher levels of these urinary substances than those (mean + 2SD) in normal controls. Screening of the 24 h-urinary albumin, BMG and NAG activity should be performed routinely in young patients with diabetes.
糖尿病患者的微量白蛋白尿被认为是早期糖尿病肾病的一个敏感指标。本文测定了41例胰岛素依赖型糖尿病儿童24小时尿白蛋白、β2微球蛋白（BMG）和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性。此外，还分析了这些物质的尿排泄量与糖尿病各种临床参数之间的关系。糖尿病儿童24小时尿白蛋白、BMG和NAG活性的平均值（均值±标准差）分别为8.0±10.6毫克/天、61.2±69.0微克/天和1.87±1.30单位/天。这些平均值在糖尿病儿童和正常对照组之间未发现显著差异。糖尿病的各种临床参数与这些物质中任何一种的尿排泄量之间也未发现显著相关性。然而，41例糖尿病儿童中有9例（22.0%）这些尿物质的水平高于正常对照组（均值+2标准差）。对于糖尿病年轻患者，应常规进行24小时尿白蛋白、BMG和NAG活性的筛查。
