Kawada T, Koyama H, Suzuki S
Department of Public Health, Gunma University School of Medicine, Maebashi, Japan.
Br J Ind Med. 1989 Jan;46(1):52-5. doi: 10.1136/oem.46.1.52.
Cadmium (Cd), N-acetyl-beta-D-glucosaminidase (NAG) activity, beta 2-microglobulin (BMG), and creatinine (cr) in urine were measured during April and September 1986 in workers exposed to cadmium pigment dust (maximum exposure 3.0 micrograms/m3/8 h for respirable dust). In April and September urinary Cd ranged from 0.2 to 9.5 and from 0.5 to 7.0 micrograms/g cr with a geometric mean of 0.7 and 1.2 micrograms/g cr, respectively. The correlation coefficient between Cd and NAG was 0.261 (n = 61) in April and 0.389 (n = 50) in September. The correlation coefficient between Cd and BMG was 0.241 (n = 63) in April and 0.115 (n = 50) in September. It appears that urinary Cd concentrations have a closer relation with urinary NAG than urinary BMG, even when urinary Cd concentrations are less than 10 micrograms/g cr. It is concluded that NAG is a more sensitive indicator of Cd absorption than BMG even at urinary Cd concentrations of less than 10 micrograms/g cr.
1986年4月至9月期间，对接触镉颜料粉尘（可吸入粉尘的最大接触量为3.0微克/立方米/8小时）的工人的尿液中的镉（Cd）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性、β2-微球蛋白（BMG）和肌酐（cr）进行了测量。4月和9月，尿镉含量分别为0.2至9.5微克/克肌酐和0.5至7.0微克/克肌酐，几何平均值分别为0.7微克/克肌酐和1.2微克/克肌酐。4月镉与NAG之间的相关系数为0.261（n = 61），9月为0.389（n = 50）。4月镉与BMG之间的相关系数为0.241（n = 63），9月为0.115（n = 50）。即使尿镉浓度低于10微克/克肌酐，尿镉浓度与尿NAG的关系似乎比与尿BMG的关系更密切。得出的结论是，即使在尿镉浓度低于10微克/克肌酐时，NAG也是比BMG更敏感的镉吸收指标。
