Tsolaki Magda, Zygouris Stelios, Lazarou Ioulietta, Kompatsiaris Ioannis, Chatzileontiadis Leontios, Votis Constantinos, Tzovaras Dimitrios, Karakostas Anastasios, Karagkiozi Constantina, Dimitriou Tatianna, Tsiatsios Thasyvoulos, Dimitriadis Stavros, Tarnanas Ioannis, Dranidis Dimitris, Bamidis Panagiotis
3rd Department of Neurology, Aristotle University of Thessaloniki, School of Medicine, Alzheimer Hellas, Thessaloniki, Grecce.
Hell J Nucl Med. 2015 Sep-Dec;18 Suppl 1:131-9.
Our research is implementing high quality next generation services for the Prediction, Early Diagnosis, Monitoring, and Support of patients with Cognitive Impairment (Subjective Cognitive Impairment -SCI-, Mild Cognitive Impairment -MCI-, Mild Dementia) and Education and Training for all stakeholders. Prediction, Early Diagnosis and Monitoring: The first idea was to Research and Develop a novel System using motion detection devices, depth cameras, and intelligent objects of everyday use (ranging from cooking implements such as kitchen to furniture (e.g. sofa, bed, etc.) which are appropriately adapted in order to capture changes of subject's Activities of Daily Living -ADL- and behavioural patterns (including mobility, nutrition, exercising and medication schedule). We also demonstrated the potential of a virtual supermarket (VSM) cognitive training game as a screening tool for patients with MCI in a sample of older adults. We have indicated that this VSM application displayed a correct classification rate (CCR) of 87.30%, achieving a level of diagnostic accuracy similar to standardized neuropsychological tests, which are the gold standard for MCI screening http://www.en-noisis.gr/ Support of patients: Cognitive tasks and cognitive exercises for patients suffering from Alzheimer's Disease (AD) through web-based applications. These exercises have been developed in such a way in order to exploit rich interactive multimedia interfaces (including music) based on human computer interaction principles. To this direction we are implementing a web based portal with supportive services such as (a) on-line monitoring of patient's progress by health care professionals, (b) statistical representation of patients' progress. Multimedia enriched cognitive exercises in virtual reality form (i.e. 3D Serious Games) use suitable modalities for such activities through the creation probable of new brain cells and by assisting the brain to find out alternative methods to execute functions, which are controlled by damaged brain regions. Another program the "robot-programming-as-cognitive-training" approach aims to explore the impact that the activity of programming a friendly robot might have on AD and MCI patients' condition. http://aspad.csd.auth.gr. Another study aimed at investigating the benefits of combined physical and cognitive training on global cognition while assessing the effect of training dosage and exploring the role of several potential effect modifiers. The results indicate that combined physical and cognitive training improves global cognition in a dose-responsive manner but these benefits may be less pronounced in older adults with mild dementia. The long-lasting impact of combined training on the incidence and trajectory of cognitive disorders in relation to its severity should be assessed in future long-term trials. www.longlastingmemories.eu. Finally, Symbiosis is a revolutionary system aiming at providing integrated solutions to a series of problems related with MCI and AD. It is the first integrated AD support system that takes into account patient's response in an adaptive way that fulfills each patient's special needs and provides to caregivers and doctors considerable facilitations, unlocking the potential of innovative supporting role. www.youtube.com/watch?v=BDkLz-T-jYE. Education and training for all stakeholders (i.e. health professionals and informal and formal caregivers) through distance education platforms and e-collaboration services. To augment this effort, the research team integrates biofeedback modules for stress measurement in teleconferences in order to support the emotional awareness of the participants. The depression, anxiety and burden of caregivers were reduced significantly in the same way as in a face to face intervention. http://aspad.csd.auth.gr. In conclusion ICT can help health professionals and caregivers to support in a better way the patients with cognitive, functional and behavioral problems.
我们的研究正在为认知障碍患者(主观认知障碍 -SCI-、轻度认知障碍 -MCI-、轻度痴呆)提供高质量的下一代预测、早期诊断、监测和支持服务,并为所有利益相关者提供教育和培训。预测、早期诊断和监测:最初的想法是研发一种新型系统,该系统使用运动检测设备、深度摄像头以及日常智能物品(从厨房用具等烹饪器具到家具(如沙发、床等)),这些物品经过适当改造,以捕捉受试者日常生活活动 -ADL- 的变化和行为模式(包括行动能力、营养、锻炼和用药时间表)。我们还在一组老年人样本中展示了虚拟超市(VSM)认知训练游戏作为MCI患者筛查工具的潜力。我们指出,这种VSM应用的正确分类率(CCR)为87.30%,达到了与标准化神经心理测试相似的诊断准确率,而标准化神经心理测试是MCI筛查的金标准http://www.en-noisis.gr/ 患者支持:通过基于网络的应用程序为阿尔茨海默病(AD)患者提供认知任务和认知训练。这些训练以利用基于人机交互原则的丰富交互式多媒体界面(包括音乐)的方式开发。在此方向上,我们正在实施一个基于网络的门户,提供诸如(a)医疗保健专业人员对患者进展的在线监测,(b)患者进展的统计呈现等支持服务。虚拟现实形式(即3D严肃游戏)的多媒体丰富认知训练通过创造新脑细胞的可能性并协助大脑找到执行由受损脑区控制的功能的替代方法,为这类活动使用合适的方式。另一个项目“机器人编程作为认知训练”方法旨在探索对友好机器人进行编程的活动可能对AD和MCI患者状况产生的影响。http://aspad.csd.auth.gr。另一项研究旨在调查身体和认知联合训练对整体认知的益处,同时评估训练剂量的效果并探索几个潜在效应修饰因素的作用。结果表明,身体和认知联合训练以剂量反应方式改善整体认知,但这些益处可能在轻度痴呆的老年人中不太明显。联合训练对认知障碍的发生率和轨迹及其严重程度的长期影响应在未来的长期试验中进行评估。www.longlastingmemories.eu。最后,共生是一个革命性的系统,旨在为与MCI和AD相关的一系列问题提供综合解决方案。它是第一个以自适应方式考虑患者反应的综合AD支持系统,满足每个患者的特殊需求,并为护理人员和医生提供极大便利,释放创新支持作用的潜力。www.youtube.com/watch?v=BDkLz-T-jYE。通过远程教育平台和电子协作服务为所有利益相关者(即卫生专业人员以及非正式和正式护理人员)提供教育和培训。为加强这一努力,研究团队在电话会议中集成了用于压力测量的生物反馈模块,以支持参与者的情绪意识。护理人员的抑郁、焦虑和负担与面对面干预一样显著降低。http://aspad.csd.auth.gr。总之,信息通信技术可以帮助卫生专业人员和护理人员更好地支持有认知、功能和行为问题的患者。