School of Psychology, Aristotle University of Thessaloniki, Greece.
Centre for Research and Technology Hellas/ Information Technologies Institute, Thessaloniki, Greece.
J Alzheimers Dis. 2021;79(4):1747-1759. doi: 10.3233/JAD-201300.
Electroencephalography (EEG) has been used to assess brain activity while users are playing an immersive serious game.
To assess differences in brain activation as measured with a non-intrusive wearable EEG device, differences in game performance and correlations between EEG power, game performance and global cognition, between cognitively impaired and non-impaired older adults, during the administration of a novel self-administered serious game-based test, the Virtual Supermarket Test (VST).
43 older adults with subjective cognitive decline (SCD) and 33 older adults with mild cognitive impairment (MCI) were recruited from day centers for cognitive disorders. Global cognition was assessed with the Montreal Cognitive Assessment (MoCA). Brain activity was measured with a non-intrusive wearable EEG device in a resting state condition and while they were administered the VST.
During resting state condition, the MCI group showed increased alpha, beta, delta, and theta band power compared to the SCD group. During the administration of the VST, the MCI group showed increased beta and theta band power compared to the SCD group. Regarding game performance, alpha, beta, delta, and theta rhythms were positively correlated with average duration, while delta rhythm was positively correlated with mean errors. MoCA correlated with alpha, beta, delta, and theta rhythms and with average game duration and mean game errors indicating that elevated EEG rhythms in MCI may be associated with an overall cognitive decline.
VST performance can be used as a digital biomarker. Cheap commercially available wearable EEG devices can be used for obtaining brain activity biomarkers.
脑电图（EEG）已被用于评估用户在玩沉浸式严肃游戏时的大脑活动。
使用非侵入性可穿戴 EEG 设备评估认知障碍和非认知障碍老年人在进行新型自我管理严肃游戏测试，即虚拟超市测试（VST）时大脑激活的差异、游戏表现的差异以及 EEG 功率、游戏表现和整体认知之间的相关性。
从认知障碍日间中心招募了 43 名有主观认知下降（SCD）的老年人和 33 名有轻度认知障碍（MCI）的老年人。整体认知通过蒙特利尔认知评估（MoCA）进行评估。在静息状态和进行 VST 时，使用非侵入性可穿戴 EEG 设备测量大脑活动。
在静息状态下，与 SCD 组相比，MCI 组的 alpha、beta、delta 和 theta 波段功率增加。在进行 VST 时，与 SCD 组相比，MCI 组的 beta 和 theta 波段功率增加。关于游戏表现，alpha、beta、delta 和 theta 节律与平均持续时间呈正相关，而 delta 节律与平均错误呈正相关。MoCA 与 alpha、beta、delta 和 theta 节律以及平均游戏持续时间和平均游戏错误呈正相关，表明 MCI 中升高的 EEG 节律可能与整体认知下降有关。
VST 表现可用作数字生物标志物。便宜的商用可穿戴 EEG 设备可用于获取大脑活动生物标志物。
