基于DNA模板化银纳米簇模板转换的纳米簇信标。
A nanocluster beacon based on the template transformation of DNA-templated silver nanoclusters.
作者信息
Teng Ye, Jia Xiaofang, Zhang Shan, Zhu Jinbo, Wang Erkang
机构信息
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
出版信息
Chem Commun (Camb). 2016 Jan 28;52(8):1721-4. doi: 10.1039/c5cc09138a. Epub 2015 Dec 15.
PMID:26666564
Abstract
In this work, we developed a novel light-up nanocluster beacon (NCB) based on shuttling dark silver nanoclusters (NCs) to a bright scaffold through hybridization. The fluorescence enhancement was as high as 70-fold when the two templates were on the opposite sides of the duplexes, enabling sensitive and selective detection of DNA.
摘要
在这项工作中，我们开发了一种新型的点亮型纳米簇信标（NCB），它基于通过杂交将暗态银纳米簇（NCs）穿梭至明亮的支架上。当两个模板位于双链体的相对侧时，荧光增强高达70倍，从而能够对DNA进行灵敏且选择性的检测。
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