Eya 磷酸酪氨酸磷酸酶的多种功能。
Multiple Functions of the Eya Phosphotyrosine Phosphatase.
作者信息
Rebay Ilaria
机构信息
Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, USA
出版信息
Mol Cell Biol. 2015 Dec 14;36(5):668-77. doi: 10.1128/MCB.00976-15.
Abstract
Eyes absent (Eya), a protein conserved from plants to humans and best characterized as a transcriptional coactivator, is also the prototype for a novel class of eukaryotic aspartyl protein tyrosine phosphatases. This minireview discusses recent breakthroughs in elucidating the substrates and cellular events regulated by Eya's tyrosine phosphatase function and highlights some of the complexities, new questions, and surprises that have emerged from efforts to understand how Eya's unusual multifunctionality influences developmental regulation and signaling.
摘要
眼缺失蛋白（Eya）是一种从植物到人类都保守的蛋白质，其最典型的特征是作为转录共激活因子，它也是一类新型真核天冬氨酸蛋白酪氨酸磷酸酶的原型。本综述讨论了在阐明由Eya酪氨酸磷酸酶功能调控的底物和细胞事件方面的最新突破，并强调了在理解Eya不同寻常的多功能性如何影响发育调控和信号传导过程中出现的一些复杂性、新问题和意外发现。
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