Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, U.S.A.
Biochem Soc Trans. 2021 Jun 30;49(3):1397-1408. doi: 10.1042/BST20201302.
The Eyes Absent (EYA) transactivator-phosphatase proteins are important contributors to cell-fate determination processes and to the development of multiple organs. The transcriptional regulatory activity as well as the protein tyrosine phosphatase activities of the EYA proteins can independently contribute to proliferation, differentiation, morphogenesis and tissue homeostasis in different contexts. Aberrant EYA levels or activity are associated with numerous syndromic and non-syndromic developmental disorders, as well as cancers. Commensurate with the multiplicity of biochemical activities carried out by the EYA proteins, they impact upon a range of cellular signaling pathways. Here, we provide a broad overview of the roles played by EYA proteins in development, and highlight the molecular signaling pathways known to be linked with EYA-associated organ development and developmental disorders.
EYA（眼睛缺失）转录激活-磷酸酶蛋白是细胞命运决定过程和多种器官发育的重要贡献者。EYA 蛋白的转录调控活性以及蛋白酪氨酸磷酸酶活性可以在不同的环境中独立促进增殖、分化、形态发生和组织内稳态。异常的 EYA 水平或活性与许多综合征和非综合征发育障碍以及癌症有关。与 EYA 蛋白所进行的多种生化活性相一致，它们影响一系列细胞信号通路。在这里，我们提供了 EYA 蛋白在发育中的作用的广泛概述，并强调了与 EYA 相关的器官发育和发育障碍相关的已知分子信号通路。
