Zhang Lei, Chen Ying, Liu Wenxin, Wang Ke
a Department of Gynecologic Oncology , Tianjin Medical University Cancer Institute and Hospital , Tianjin , China .
b Key Laboratory of Cancer Prevention and Therapy , Tianjin , China , and.
Biomarkers. 2016;21(2):168-72. doi: 10.3109/1354750X.2015.1118552. Epub 2015 Dec 15.
This study aimed to evaluate the clinical significances of human epididymis protein 4 (HE4) with cancer antigen 125 (CA125) in differential diagnosis between epithelial ovarian cancer (EOC) and peritoneal tuberculosis (PTB). We retrospectively reviewed data of 31 patients suspected preoperatively as having EOC but whose pathological results revealed PTB. The concentrations of serum HE4 and CA125 in PTB were significantly lower than that in EOC. The optimal cutoffs to differentiate EOC from PTB were HE4 > 151.4 pmol/l and CA125 > 563.5 U/ml, which means EOC may be considered if HE4 or CA125 was greater than the cutoff, otherwise, PTB should not be neglected. Furthermore, the specificity and accuracy for differentiating PTB form EOC could be improved when combination HE4 and CA125. Conclusively, the combination of HE4 and CA125 may be recommended as potential biomarkers in the preliminary differential diagnosis of PTB from EOC before the "golden standard" of pathologic diagnosis finally obtained.
本研究旨在评估人附睾蛋白4（HE4）与癌抗原125（CA125）在上皮性卵巢癌（EOC）和腹膜结核（PTB）鉴别诊断中的临床意义。我们回顾性分析了31例术前疑似患有EOC但病理结果显示为PTB患者的数据。PTB患者血清HE4和CA125浓度显著低于EOC患者。鉴别EOC与PTB的最佳临界值为HE4＞151.4 pmol/l和CA125＞563.5 U/ml，这意味着若HE4或CA125大于临界值，则可能为EOC，否则，PTB也不应被忽视。此外，联合检测HE4和CA125可提高鉴别PTB与EOC的特异性和准确性。总之，在最终获得病理诊断这一“金标准”之前，HE4和CA125联合检测可作为PTB与EOC初步鉴别诊断的潜在生物标志物。
