Guynn R W, Faillace L A
J Clin Psychiatry. 1978 Jun;39(6):523, 527-31.
The widespread use of synthetic organic fluorides has recently received attention as a potential health hazard. There are a number of organic fluorides which have become important considerations in psychiatry. Therapeutically the organic fluorides include the neuroleptics trifluoperazine, fluphenazine, triflupromazine, and haloperidol, the benzodiazepine flurazepam and the polyfluorinated inhalant convulsant indoklon. On the negative side, deliberate inhalation of fluorocarbon aerosol propellants has become a modern form of drug abuse among the young. A review is presented on the biochemistry and toxicology of organic fluorides with special emphasis on implications to the field of psychiatry.
合成有机氟化物的广泛使用最近作为一种潜在的健康危害受到了关注。有多种有机氟化物已成为精神病学中的重要考量因素。在治疗方面，有机氟化物包括抗精神病药物三氟拉嗪、氟奋乃静、三氟丙嗪和氟哌啶醇、苯二氮䓬类药物氟西泮以及多氟吸入性惊厥剂恩丹西酮。负面的是，故意吸入碳氟化合物气溶胶推进剂已成为年轻人中一种现代形式的药物滥用。本文对有机氟化物的生物化学和毒理学进行了综述，特别强调了其对精神病学领域的影响。
