Avella Joseph, Wilson James C, Lehrer Michael
Department of Forensic Toxicology, Suffolk County Office of the Medical Examiner, Hauppauge, New York 11788, USA.
Am J Forensic Med Pathol. 2006 Mar;27(1):58-60. doi: 10.1097/01.paf.0000202715.71009.0e.
A 42-year-old man was found dead after repeated exposure to 1,1-difluoroethane (DFE, Freon 152a), a propellant found in CRC Duster, a product intended for the removal of dust and lint. Toxicologic analysis detected DFE in femoral blood 136.3 mg/L, brain 117.5 mg/kg, liver 87.6 mg/kg, lung 60.3 mg/kg, adipose 235.7 mg/kg, and vitreous fluid 25.1 mg/L. The cause of death was determined to be a fatal cardiac arrhythmia due to intoxication with 1,1-difluoroethane. After comparison to previously published cases involving DFE, we suggest that analysis of adipose tissue for DFE and similar compounds, along with blood and other tissues, may be useful in distinguishing between acute versus chronic exposure. Adipose may also be a valuable alternate specimen for detection in cases where loss or elimination from blood is likely to have occurred.
一名42岁男子在反复接触1,1 - 二氟乙烷（DFE，氟利昂152a）后死亡，DFE是一种用于去除灰尘和绒毛的产品CRC Duster中的推进剂。毒理学分析在股血中检测到DFE的含量为136.3毫克/升，脑中为117.5毫克/千克，肝脏中为87.6毫克/千克，肺中为60.3毫克/千克，脂肪中为235.7毫克/千克，玻璃体液中为25.1毫克/升。死亡原因被确定为因1,1 - 二氟乙烷中毒导致的致命心律失常。与之前发表的涉及DFE的病例进行比较后，我们建议对脂肪组织以及血液和其他组织进行DFE和类似化合物的分析，可能有助于区分急性暴露与慢性暴露。在可能发生血液中物质丢失或消除的情况下，脂肪也可能是用于检测的有价值的替代样本。
