女性家庭照顾者的宗教参与度与端粒长度
Religious Involvement and Telomere Length in Women Family Caregivers.
作者信息
Koenig Harold G, Nelson Bruce, Shaw Sally F, Saxena Salil, Cohen Harvey Jay
机构信息
*Duke University Medical Center, Durham, NC; †King Abdulaziz University, Jeddah, Saudi Arabia; ‡Ningxia Medical University, Yinchuan, PR China; §Department of Research, Glendale Adventist Medical Center, Glendale, CA; and ∥Center for Aging and Human Development, Duke University Medical Center, Durham, NC.
出版信息
J Nerv Ment Dis. 2016 Jan;204(1):36-42. doi: 10.1097/NMD.0000000000000443.
Telomere length (TL) is an indicator of cellular aging associated with longevity and psychosocial stress. We examine here the relationship between religious involvement and TL in 251 stressed female family caregivers recruited into a 2-site study. Religious involvement, perceived stress, caregiver burden, depressive symptoms, and social support were measured and correlated with TL in whole blood leukocytes. Results indicated a U-shaped relationship between religiosity and TL. Those scoring in the lowest 10% on religiosity tended to have the longest telomeres (5743 bp ± 367 vs. 5595 ± 383, p = 0.069). However, among the 90% of caregivers who were at least somewhat religious, religiosity was significantly and positively related to TL after controlling for covariates (B = 1.74, SE = 0.82, p = 0.034). Whereas nonreligious caregivers have relatively long telomeres, we found a positive relationship between religiosity and TL among those who are at least somewhat religious.
端粒长度（TL）是一种与长寿和心理社会压力相关的细胞衰老指标。我们在此研究了251名被招募到一项双地点研究中的压力较大的女性家庭照顾者的宗教参与度与端粒长度之间的关系。对宗教参与度、感知压力、照顾者负担、抑郁症状和社会支持进行了测量，并将其与全血白细胞中的端粒长度进行了相关性分析。结果表明，宗教信仰与端粒长度之间呈U形关系。宗教信仰得分处于最低10%的人往往端粒最长（5743碱基对±367对5595±383，p = 0.069）。然而，在至少有一定宗教信仰的90%的照顾者中，在控制协变量后，宗教信仰与端粒长度呈显著正相关（B = 1.74，标准误 = 0.82，p = 0.034）。虽然无宗教信仰的照顾者端粒相对较长，但我们发现，在至少有一定宗教信仰的人群中，宗教信仰与端粒长度呈正相关。
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