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[胰腺手术中的血管切除与重建技术]

[Vascular resection and reconstruction techniques in pancreatic surgery].

作者信息

Klose J, Hackert T, Büchler M W, Ulrich A

机构信息

Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universität Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland.

出版信息

Chirurg. 2016 Feb;87(2):94-9. doi: 10.1007/s00104-015-0134-5.

Abstract

BACKGROUND

Vascular resection interventions and the associated necessity of a reconstruction for maintenance particularly of hepatic and small intestinal perfusion are important aspects especially for the surgical treatment of pancreatic cancer. An R0 resection is the only curative treatment option for patients with pancreatic cancer. Venous or arterial vascular infiltration by the tumor and the associated resection and reconstruction for complete tumor removal and establishment of a sufficient perfusion of the dependent organs represents one of the greatest challenges in pancreatic surgery. In addition the oncological significance with respect to arterial vascular resections is controversial.

OBJECTIVE

In this review article the indications and technical aspects of vascular resection and reconstruction in the therapy of pancreatic cancer are presented and discussed based on the current literature.

MATERIAL AND METHODS

A systematic search of Medline, Embase and the Cochrane Library was carried out to identify studies reporting the results of venous or arterial vascular resection techniques, postoperative morbidity, mortality and patient survival after surgery for pancreatic cancer. Results Pancreatic cancer with vascular infiltration should not principally be seen as non-resectable but must always be checked for the possibility of a curative resection. A decisive factor is the differentiation between venous and arterial vascular involvement. Various safe technical options are available for venous vascular resection, depending on the extent of tumor infiltration. Arterial vascular resections are associated with an increased morbidity and mortality. In selected patients a complete tumor resection and prolonged survival can be achieved by arterial vascular resection.

摘要

背景

血管切除干预措施以及为维持肝脏和小肠灌注而进行重建的必要性是胰腺癌外科治疗的重要方面,尤其是在维持肝脏和小肠灌注方面。R0切除是胰腺癌患者唯一的治愈性治疗选择。肿瘤侵犯静脉或动脉血管以及为完全切除肿瘤并建立对依赖器官的充分灌注而进行的相关切除和重建是胰腺手术中最大的挑战之一。此外,动脉血管切除的肿瘤学意义存在争议。

目的

在这篇综述文章中,基于当前文献介绍并讨论了胰腺癌治疗中血管切除和重建的适应证及技术要点。

材料与方法

对Medline、Embase和Cochrane图书馆进行系统检索,以确定报告胰腺癌手术后静脉或动脉血管切除技术结果、术后发病率、死亡率和患者生存率的研究。结果:伴有血管侵犯的胰腺癌原则上不应被视为不可切除,但必须始终检查是否有可能进行根治性切除。一个决定性因素是区分静脉和动脉血管受累情况。根据肿瘤浸润程度,有多种安全的静脉血管切除技术可供选择。动脉血管切除与发病率和死亡率增加相关。在选定的患者中,通过动脉血管切除可以实现肿瘤的完全切除并延长生存期。

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