Can ARFI elastometry of the salivary glands contribute to the diagnosis of Sjögren's syndrome?

OBJECTIVES

The diagnosis of primary Sjögren's syndrome (pSS) rests on a converging set of clinical and laboratory findings. Salivary-gland ultrasonography (SGUS) was recently shown to assist in the diagnosis and therapeutic monitoring of pSS. Our objective here was to measure salivary-gland elasticity using Acoustic Radiation Force Impulse (ARFI) ultrasonography in patients with pSS and to compare the results to those obtained in healthy controls.

METHODS

SGUS with ARFI elastometry was performed in 10 patients with pSS and 15 healthy controls. Ten impulses per gland were used for both submandibular and both parotid glands of each participant. Mean shear wave velocity (SWV) in m/s was compared between the patients and controls using the Mann-Whitney U test.

RESULTS

For the parotid glands, mean SWV was significantly higher in the pSS group than in the control group (2.335±0.315 vs 1.785±0.384, respectively; P=0.001). Mean SWV values for the submandibular glands were not significantly different between the patients and controls (1.812±0.308 vs 1.766±0.187, respectively; P=0.892).

CONCLUSION

ARFI elastometry may contribute to the diagnosis of pSS, as this noninvasive, fast, and inexpensive investigation can demonstrate abnormal architectural changes in the parotid glands.