Nygren Ulrika, Nordenskjöld Agneta, Arver Stefan, Södersten Maria
Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Division of Speech and Language Pathology, SE-171 77 Stockholm, Sweden; Karolinska University Hospital, Department of Speech and Language Pathology, SE-171 76 Stockholm, Sweden.
Karolinska Institutet, Department of Women's and Children's Health and Center of Molecular Medicine, SE-171 77 Stockholm, Sweden; Karolinska University Hospital, Department of Paediatric Surgery, Astrid Lindgren Children's Hospital, SE-171 76 Stockholm, Sweden.
J Voice. 2016 Nov;30(6):766.e23-766.e34. doi: 10.1016/j.jvoice.2015.10.016. Epub 2015 Dec 8.
To investigate effects of testosterone treatment regarding voice virilization, voice problems, and voice satisfaction in transsexual female-to-male individuals, referred to as trans men.
Longitudinal.
Fifty trans men, diagnosed with transsexualism, 18-64 years, met the inclusion criteria. Voice data before treatment and after 3, 6, or 12 months were available from 49 participants, and for 28 participants also after 18 and/or 24 months of treatment. Digital audio recordings of speech range profiles and voice range profiles were carried out in a sound-treated booth following clinical routines. Acoustic analyses of fundamental frequency (F0) and sound pressure level were made. Endocrine data and answers from questionnaires concerning voice function and voice problems were collected from medical records.
Mean F0 and mode F0 of the habitual voice decreased significantly after 3 months, 6 months, and up to 12 months, when group data were congruent with reference data for males. Mean F0 was 125 Hz after 12 months with a large interindividual variation. Sound pressure level values did not change significantly. Voice satisfaction correlated with lower F0 values. Twenty-four percent of the participants reported voice symptoms, for example, vocal instability and fatigue, and had received voice therapy. F0 values did not correlate with androgen levels.
Most trans men developed a male voice and were satisfied. However, it is important to detect the substantial group of trans men with voice problems and with insufficient voice virilization and who may need voice therapy. Therefore, we recommend systematic voice assessments during testosterone treatment.
研究睾酮治疗对变性女性转男性个体（即跨性别男性）声音男性化、声音问题及声音满意度的影响。
纵向研究。
50名被诊断为变性症的跨性别男性，年龄在18至64岁之间，符合纳入标准。49名参与者可获得治疗前以及治疗3、6或12个月后的声音数据，28名参与者在治疗18和/或24个月后也有相关数据。按照临床常规，在隔音室中进行语音音域轮廓和嗓音音域轮廓的数字音频录制。对基频（F0）和声压级进行声学分析。从医疗记录中收集内分泌数据以及有关声音功能和声音问题的问卷调查答案。
当组数据与男性参考数据一致时，习惯性声音的平均F0和众数F0在3个月、6个月以及直至12个月后均显著下降。12个月后平均F0为125Hz，个体间差异较大。声压级值无显著变化。声音满意度与较低的F0值相关。24%的参与者报告了声音症状，例如声音不稳定和疲劳，并接受了嗓音治疗。F0值与雄激素水平无关。
大多数跨性别男性形成了男性化声音并感到满意。然而，检测出大量存在声音问题、声音男性化不足且可能需要嗓音治疗的跨性别男性很重要。因此，我们建议在睾酮治疗期间进行系统的声音评估。
