Schwarzova L, Hubacek J A, Vrablik M
Third Department of Internal Medicine, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Physiol Res. 2015;64(Suppl 3):S341-54. doi: 10.33549/physiolres.933197.
The issue of plasma triglyceride levels relative to the risk of development of cardiovascular disease, as well as overall mortality, has been actively discussed for many years. Like other cardiovascular disease risk factors, final plasma TG values have environmental influences (primarily dietary habits, physical activity, and smoking), and a genetic predisposition. Rare mutations (mainly in the lipoprotein lipase and apolipoprotein C2) along with common polymorphisms (within apolipoprotein A5, glucokinase regulatory protein, apolipoprotein B, apolipo-protein E, cAMP responsive element binding protein 3-like 3, glycosylphosphatidylinositol-anchored HDL-binding protein 1) play an important role in determining plasma TG levels.
关于血浆甘油三酯水平与心血管疾病发生风险以及总体死亡率的问题，多年来一直受到积极讨论。与其他心血管疾病风险因素一样，最终的血浆甘油三酯值受环境影响（主要是饮食习惯、身体活动和吸烟）以及遗传易感性的影响。罕见突变（主要存在于脂蛋白脂肪酶和载脂蛋白C2中）以及常见多态性（存在于载脂蛋白A5、葡萄糖激酶调节蛋白、载脂蛋白B、载脂蛋白E、cAMP反应元件结合蛋白3样3、糖基磷脂酰肌醇锚定的高密度脂蛋白结合蛋白1中）在决定血浆甘油三酯水平方面发挥着重要作用。
