The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan.
Int J Med Sci. 2018 Jun 14;15(10):1035-1042. doi: 10.7150/ijms.25742. eCollection 2018.
Chromosome 12q23-q24 has been linked to triglyceride (TG) levels by previous linkage studies, and it contains the () gene. We investigated the association between and TG levels using two independent samples collected in Taiwan. First, based on 954 siblings in 397 families from the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe), we found that rs978458 was associated with TG levels ( = -0.049, = 0.0043) under a recessive genetic model. Specifically, subjects carrying the homozygous genotype of the minor allele had lower TG levels, compared with other subjects. Then, a series of stratification analyses in a large sample of 13,193 unrelated subjects from the Taiwan biobank (TWB) project showed that this association appeared in subjects with a family history (FH) of hypertension ( = -0.045, = 0.0000034), but not in subjects without such an FH. A re-examination of the SAPPHIRe sample confirmed that this association appeared in subjects with an FH of hypertension ( = -0.068, = 0.0025), but not in subjects without an FH. The successful replication in two independent samples indicated that is associated with TG levels in subjects with an FH of hypertension in Taiwan.
先前的连锁研究将 12q23-q24 染色体与甘油三酯 (TG) 水平联系起来，该区域包含 基因。我们使用在台湾收集的两个独立样本，研究了 与 TG 水平之间的关联。首先，基于斯坦福亚太高血压和胰岛素抵抗计划（SAPPHIRe）的 397 个家庭中的 954 个兄弟姐妹，我们发现 rs978458 在隐性遗传模型下与 TG 水平相关（ = -0.049， = 0.0043）。具体而言，与携带次要等位基因纯合基因型的受试者相比，其他受试者的 TG 水平较低。然后，在来自台湾生物银行（TWB）项目的 13193 名无关受试者的大型样本中进行了一系列分层分析，结果表明这种关联存在于具有高血压家族史（FH）的受试者中（ = -0.045， = 0.0000034），但不存在于没有 FH 的受试者中。对 SAPPHIRe 样本的重新检查证实，这种关联存在于具有高血压 FH 的受试者中（ = -0.068， = 0.0025），但不存在于没有 FH 的受试者中。在两个独立样本中的成功复制表明，在台湾具有高血压 FH 的受试者中，与 TG 水平相关。
