Poledne R, Králová Lesná I, Čejková S
Laboratory for Atherosclerosis Research, Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.
Physiol Res. 2015;64(Suppl 3):S395-402. doi: 10.33549/physiolres.933152.
High-energy intake which exceeds energy expenditure leads to the accumulation of triglycerides in adipose tissue, predominantly in large-size adipocytes. This metabolic shift, which drives the liver to produce atherogenic dyslipidemia, is well documented. In addition, an increasing amount of monocytes/macrophages, predominantly the proinflammatory M1-type, cumulates in ectopic adipose tissue. The mechanism of this process, the turnover of macrophages in adipose tissue and their direct atherogenic effects all remain to be analyzed.
超过能量消耗的高能量摄入会导致甘油三酯在脂肪组织中积累，主要是在大型脂肪细胞中。这种导致肝脏产生动脉粥样硬化性血脂异常的代谢转变已有充分记录。此外，越来越多的单核细胞/巨噬细胞，主要是促炎M1型，在异位脂肪组织中积累。这个过程的机制、脂肪组织中巨噬细胞的更新及其直接的动脉粥样硬化作用都有待分析。
