From the Center for Systems Biology, Department of Imaging (L.H., M.N.) and Cardiovascular Research Center (M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Circ Res. 2018 Jan 5;122(1):113-127. doi: 10.1161/CIRCRESAHA.117.311071.
Macrophages are ubiquitous cells that reside in all major tissues. Counter to long-held beliefs, we now know that resident macrophages in many organs are seeded during embryonic development and self-renew independently from blood monocytes. Under inflammatory conditions, those tissue macrophages are joined and sometimes replaced by recruited monocyte-derived macrophages. Macrophage function in steady state and disease depends on not only their developmental origin but also the tissue environment. Here, we discuss the ontogeny, function, and interplay of tissue-resident and monocyte-derived macrophages in various organs contributing to the development and progression of cardiovascular disease.
巨噬细胞是广泛存在于所有主要组织中的细胞。与长期以来的观点相反，我们现在知道，许多器官中的常驻巨噬细胞是在胚胎发育过程中形成的，并独立于血液单核细胞自我更新。在炎症条件下，这些组织巨噬细胞会被募集的单核细胞衍生的巨噬细胞融合并取代。巨噬细胞在稳态和疾病中的功能不仅取决于其发育起源，还取决于组织环境。在这里，我们讨论了在各种组织中发挥作用的组织驻留巨噬细胞和单核细胞衍生巨噬细胞的个体发生、功能和相互作用，这些巨噬细胞有助于心血管疾病的发展和进展。
