心血管疾病中的一种新型肽——内脂素。
A novel peptide adropin in cardiovascular diseases.
作者信息
Li Liang, Xie Wei, Zheng Xi-Long, Yin Wei-Dong, Tang Chao-Ke
机构信息
Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China; Department of Pathophysiology, University of South China, Hengyang 421001, Hunan, China.
Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China; Department of Anatomy, University of South China, Hengyang 421001, Hunan, China.
出版信息
Clin Chim Acta. 2016 Jan 30;453:107-13. doi: 10.1016/j.cca.2015.12.010. Epub 2015 Dec 10.
Cardiovascular diseases, such as atherosclerosis and hypertension, are the major cause of mortality and morbidity in the world. Adropin was first discovered in 2008 by Kumar and his coworkers. Adropin, encoded by the Energy Homeostasis Associated gene, is expressed in many tissues and organs, such as pancreatic tissue, liver, brain, kidney, endocardium, myocardium, and epicardium. In this review, we have summarized recent data suggesting the roles of adropin in several major cardiovascular diseases. Increasing evidence suggests that adropin is a potential regulator of cardiovascular functions and plays a protective role in the pathogenesis and development of cardiovascular diseases. However, further studies are needed to elucidate the specific mechanisms underlying the association between adropin and cardiovascular diseases.
心血管疾病，如动脉粥样硬化和高血压，是全球死亡率和发病率的主要原因。2008年，库马尔及其同事首次发现了内脂素。内脂素由能量稳态相关基因编码，在许多组织和器官中表达，如胰腺组织、肝脏、大脑、肾脏、心内膜、心肌和心外膜。在本综述中，我们总结了最近的数据，这些数据表明内脂素在几种主要心血管疾病中的作用。越来越多的证据表明，内脂素是心血管功能的潜在调节因子，在心血管疾病的发病机制和发展过程中发挥保护作用。然而，需要进一步的研究来阐明内脂素与心血管疾病之间关联的具体机制。
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