Department of Nephrology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, P.R. China.
Department of Nephrology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, P.R. China.
Int J Mol Med. 2024 Oct;54(4). doi: 10.3892/ijmm.2024.5414. Epub 2024 Aug 19.
Adropin is a secreted peptide encoded by the energy homeostasis‑associated gene, which also functions as a membrane‑bound protein facilitating intercellular communication. This peptide has been detected in various tissues and body fluids, including the brain, liver, kidney, heart, pancreas, small intestine, endothelial cells and colostrum. Notably, the amino acid sequences of adropin are identical in humans, mice and rats. Previous studies have demonstrated that adropin levels fluctuate under different physiological and pathological conditions. Adropin plays a role in regulating carbohydrate metabolism, lipid metabolism and intercellular molecular signaling pathways, implicating its involvement in the progression of numerous diseases, such as acute myocardial infarction, lung injury, non‑alcoholic fatty liver disease/non‑alcoholic steatohepatitis, kidney disease, polycystic ovary syndrome, obesity, and diabetes, atherosclerosis, systemic sclerosis and cancer. Despite its significance, the precise role and mechanism of this protein remain inadequately understood and studied. To elucidate the function of adropin and its clinical research status, a systematic review of recent studies on adropin across various diseases was conducted. Additionally, several challenges and limitations associated with adropin research in both animal and clinical contexts were identified, aiming to offer valuable insights for future investigation.
分泌素是能量平衡相关基因编码的一种分泌肽，也作为一种膜结合蛋白发挥作用，促进细胞间通讯。这种肽已在各种组织和体液中被检测到，包括大脑、肝脏、肾脏、心脏、胰腺、小肠、内皮细胞和初乳。值得注意的是，分泌素在人类、小鼠和大鼠中的氨基酸序列完全相同。先前的研究表明，分泌素水平在不同的生理和病理条件下波动。分泌素在调节碳水化合物代谢、脂质代谢和细胞间分子信号通路方面发挥作用，表明其参与了许多疾病的进展，如急性心肌梗死、肺损伤、非酒精性脂肪性肝病/非酒精性脂肪性肝炎、肾脏疾病、多囊卵巢综合征、肥胖和糖尿病、动脉粥样硬化、系统性硬化症和癌症。尽管它具有重要意义，但这种蛋白质的确切作用和机制仍未得到充分理解和研究。为了阐明分泌素的功能及其临床研究现状，对各种疾病中分泌素的最新研究进行了系统综述。此外，还确定了与动物和临床环境中分泌素研究相关的一些挑战和限制，旨在为未来的研究提供有价值的见解。
