González Baldomero, Vargas Guadalupe, Espinosa Etual, Mendoza-Zubieta Victoria, Ferreira-Hermosillo Aldo, Zárate Aldo, Rodríguez Adolfo, Mercado Moisés
Endocr Pract. 2016 May;22(5):540-5. doi: 10.4158/EP151100.OR. Epub 2015 Dec 18.
Nonfunctioning pituitary adenomas (NFPAs) can be associated with significant morbidity including a compromised quality of life (QoL). Radiotherapy (RT) is listed as one of the contributing factors to QoL impairment in these patients, however the evidence supporting this association is scarce and conflicting. Here we evaluate health-related QoL (HRQoL) impairment in patients with NFPA and to what extent this is due to RT.
HRQoL was evaluated with the short form-36 questionnaire (SF-36), which explores 8 domains pertaining physical, emotional, and mental well being. We assessed 50 patients with NFPA subjected to RT after pituitary surgery, and their results were compared to those from 127 subjects who had undergone surgery but not RT. Both groups were matched for age, sex, and metabolic and cardiovascular comorbidities. The SF-36 was applied a median of 72 months after RT in the group of cases and 78 months after the last surgical procedure in the control group.
Both groups scored equally low in the 8 areas explored by the survey. In a multiple linear regression model, age was significantly associated with worse physical health scores, whereas female sex was associated with worse general health perception and lower emotional role and physical role scores. The presence of a visual field defect was significantly associated with a worse social role functioning score.
QoL in patients with NFPAs is significantly compromised in most scales evaluated by the SF-36 survey. However, RT itself does not affect QoL.
无功能垂体腺瘤（NFPA）可导致显著的发病率，包括生活质量（QoL）受损。放射治疗（RT）被列为这些患者生活质量受损的促成因素之一，然而支持这种关联的证据稀少且相互矛盾。在此，我们评估NFPA患者的健康相关生活质量（HRQoL）受损情况以及这在多大程度上归因于放疗。
采用简短健康调查问卷（SF - 36）评估HRQoL，该问卷探讨与身体、情感和心理健康相关的8个领域。我们评估了50例垂体手术后接受放疗的NFPA患者，并将其结果与127例接受了手术但未接受放疗的患者进行比较。两组在年龄、性别、代谢和心血管合并症方面进行了匹配。病例组在放疗后中位数72个月应用SF - 36，对照组在最后一次手术后78个月应用。
在调查所探索的8个领域中，两组得分均同样低。在多元线性回归模型中，年龄与较差的身体健康评分显著相关，而女性与较差的总体健康感知、较低的情感角色和身体角色评分相关。视野缺损的存在与较差的社会角色功能评分显著相关。
在SF - 36调查评估的大多数量表中，NFPA患者的生活质量显著受损。然而，放疗本身并不影响生活质量。
