Leães Cyro G S, Fernandes Matheus V, Alves Luiza, Araújo Bruna, Rech Carolina G S L, Ferreira Nelson P, Rosa Luis H T, Pereira-Lima Júlia F S, Oliveira Miriam C
Programa de Pós-Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
Centro de Neuroendocrinologia, Complexo Hospitalar Santa Casa, UFCSPA, Porto Alegre, RS, Brasil.
Indian J Endocrinol Metab. 2019 Jul-Aug;23(4):473-479. doi: 10.4103/ijem.IJEM_301_19.
Individuals with pituitary adenomas may have organic consequences of their disease or therapy, and psychological changes can compromise their quality of life (QoL). This study aimed to determine the anthropometric profile and health indicators of patients with pituitary adenoma before and after pituitary surgery.
Forty-four patients were included in this study. Out of these, 22 patients had nonfunctioning adenomas (50%), 17 acromegaly (38.6%), and 5 patients with Cushing's disease (11.4%). Anthropometric measurements included body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR). Health indicators included body fat percentage (BF%), basal metabolic rate (BMR), maximal oxygen uptake (VO max), and hand grip strength. Physical activity level (the International Physical Activity Questionnaire [IPAQ]), subjective perception of health, body image (Body Shape Questionnaire), body satisfaction (Stunkard Figure Rating Scale) were used.
The mean patient age was 47.2 ± 14.6 years; of which 25 were women (56.8%). Before surgery, 75.0% were overweight or obese, 84.1% had WC with risk of metabolic complications, and 90.0% had WHR with cardiovascular risk. There was a high BF% in 56.4% of cases, low BMR in 65.1%, lower VO max in 16.2%, and below-average grip strength in 88.6%. Hypopituitary patients had poorer cardiorespiratory fitness. The IPAQ showed reduction in physical activity, and 79.5% of patients were dissatisfied with their body image. Patients with nonfunctioning adenomas had better perception of their health while those with Cushing's disease had more distorted body image. Postoperatively, patients with acromegaly showed improvement in WHR and physical activity level, and patients with Cushing's disease showed improvement in anthropometric variables.
These findings emphasize the need for continuous monitoring of this population for anthropometric indicators associated with metabolic and cardiovascular comorbidities as well as body satisfaction.
垂体腺瘤患者可能会出现疾病本身或治疗带来的器质性后果，而心理变化会影响他们的生活质量（QoL）。本研究旨在确定垂体手术前后垂体腺瘤患者的人体测量学特征和健康指标。
本研究纳入了44例患者。其中，22例患有无功能腺瘤（50%），17例患有肢端肥大症（38.6%），5例患有库欣病（11.4%）。人体测量指标包括体重指数（BMI）、腰围（WC）和腰臀比（WHR）。健康指标包括体脂百分比（BF%）、基础代谢率（BMR）、最大摄氧量（VO max）和握力。使用了身体活动水平（国际身体活动问卷[IPAQ]）、健康主观感受、身体形象（身体形状问卷）、身体满意度（斯汤卡德体型评定量表）。
患者的平均年龄为47.2±14.6岁；其中25例为女性（56.8%）。手术前，75.0%的患者超重或肥胖，84.1%的患者腰围存在代谢并发症风险，90.0%的患者腰臀比存在心血管风险。56.4%的病例体脂百分比高，65.1%的患者基础代谢率低，16.2%的患者最大摄氧量较低，88.6%的患者握力低于平均水平。垂体功能减退患者的心肺适能较差。IPAQ显示身体活动减少，79.5%的患者对自己的身体形象不满意。无功能腺瘤患者对自身健康的认知较好，而库欣病患者的身体形象扭曲更严重。术后，肢端肥大症患者的腰臀比和身体活动水平有所改善，库欣病患者的人体测量变量有所改善。
这些发现强调了需要持续监测该人群与代谢和心血管合并症相关的人体测量指标以及身体满意度。
