Kemani M K, Hesser H, Olsson G L, Lekander M, Wicksell R K
Behavioural Medicine Pain Treatment Services, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Eur J Pain. 2016 Apr;20(4):521-31. doi: 10.1002/ejp.754. Epub 2015 Dec 18.
The utility of cognitive behavioural (CB) interventions for chronic pain has been supported in numerous studies. This includes Acceptance and Commitment Therapy (ACT), which has gained increased empirical support. Previous research suggests that improvements in pain catastrophizing and psychological inflexibility are related to improvements in treatment outcome in this type of treatment. Although a few studies have evaluated processes of change in CB-interventions, there is a particular need for mediation analyses that use multiple assessments to model change in mediators and outcome over time, and that incorporate the specified timeline between mediator and outcome in the data analytic model.
This study used session-to-session assessments to evaluate if psychological inflexibility, catastrophizing, and pain intensity mediated the effects of treatment on pain interference. Analyses were based on data from a previously conducted randomized controlled trial (n = 60) evaluating the efficacy of ACT and Applied Relaxation (AR). A moderated mediation model based on linear mixed models was used to analyse the data.
Neither catastrophizing nor pain intensity mediated changes in pain interference for any of the treatments. In contrast, psychological inflexibility mediated effects on outcome in ACT but not in AR.
Results add to previous findings illustrating the role of psychological inflexibility as a mediator in ACT.
认知行为(CB)干预对慢性疼痛的效用已在众多研究中得到证实。这包括接受与承诺疗法(ACT),该疗法已获得越来越多的实证支持。先前的研究表明,在这类治疗中,疼痛灾难化和心理灵活性的改善与治疗效果的改善相关。尽管有一些研究评估了CB干预中的变化过程,但特别需要进行中介分析,即使用多次评估来对中介变量和结果随时间的变化进行建模,并在数据分析模型中纳入中介变量和结果之间的特定时间线。
本研究采用逐节评估来评估心理灵活性、灾难化和疼痛强度是否介导了治疗对疼痛干扰的影响。分析基于先前进行的一项随机对照试验(n = 60)的数据,该试验评估了ACT和应用放松疗法(AR)的疗效。使用基于线性混合模型的调节中介模型来分析数据。
对于任何一种治疗,灾难化和疼痛强度均未介导疼痛干扰的变化。相比之下,心理灵活性介导了ACT对结果的影响,但未介导AR对结果的影响。
研究结果补充了先前的发现,阐明了心理灵活性在ACT中作为中介变量的作用。