膜接触位点的SMP结构域蛋白：结构与功能
SMP-domain proteins at membrane contact sites: Structure and function.
作者信息
Reinisch Karin M, De Camilli Pietro
机构信息
Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Department of Cell Biology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neurobiology, Howard Hughes Medical Institute, Kavli Institute for Neuroscience and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA.
出版信息
Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):924-927. doi: 10.1016/j.bbalip.2015.12.003. Epub 2015 Dec 10.
Abstract
SMP-domains are found in proteins that localize to membrane contact sites. Elucidation of the properties of these proteins gives clues as to the molecular bases underlying processes that occur at such sites. Described here are recent discoveries concerning the structure, function, and regulation of the Extended-Synaptotagmin proteins and ERMES complex subunits, SMP-domain proteins at endoplasmic reticulum (ER)-plasma membrane and ER-mitochondrial contacts, respectively. They act as tethers contributing to the architecture of these sites and as lipid transporters that convey glycerolipids between apposed membranes. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.
摘要
SMP结构域存在于定位于膜接触位点的蛋白质中。对这些蛋白质特性的阐明为发生在这些位点的过程背后的分子基础提供了线索。本文介绍了关于延伸突触结合蛋白和内质网-线粒体接触位点的ERMES复合亚基（分别是内质网-质膜和内质网-线粒体接触位点的SMP结构域蛋白）的结构、功能和调控的最新发现。它们作为连接物有助于这些位点的结构形成，并作为脂质转运体在相邻膜之间转运甘油olipids。本文是由蒂姆·P·莱文和阿南特·K·梅农编辑的特刊《细胞脂质景观》的一部分。
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