使用儿童皮肤病生活质量指数（CDLQI）衡量儿童皮肤病对生活质量的影响：一项荟萃分析。

Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis.

机构信息

Institute of Health and Wellbeing, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, U.K.

Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxford, OX3 7JX, U.K.

出版信息

Br J Dermatol. 2016 Apr;174(4):853-61. doi: 10.1111/bjd.14361. Epub 2016 Mar 6.

DOI:10.1111/bjd.14361

PMID:26686685

Abstract

BACKGROUND

The Children's Dermatology Life Quality Index (CDLQI) is the most widely used instrument for measuring the impact of skin disease on quality of life (QoL) in children.

OBJECTIVES

To provide a meta-analysis of all published QoL scores for a range of childhood skin conditions.

METHODS

Studies using the CDLQI questionnaire to measure QoL in skin conditions were identified by searching Medline and Embase from January 1995 (CDLQI creation) to December 2014. Studies were grouped according to condition and baseline scores were combined using meta-analysis.

RESULTS

Sixty-seven studies using the CDLQI met the inclusion criteria. The overall estimated CDLQI scores for conditions reported more than once were [point estimate (95% confidence interval, CI), number of studies (n), score range]: atopic eczema [8·5 (7·1-9·8), n = 38, 0-29], acne [5·3 (1·9-8·5), n = 5, 0-30], alopecia [3·1 (0-7·7), n = 2, 0-6], molluscum contagiosum [3·5 (0·6-6·7), n = 5, 0-27], psoriasis [8·0 (3·9-12·1), n = 6, 0-29], scabies [9·2 (0·0-20·3), n = 2, 1-26], urticaria [7·1 (0-15·4), n = 2, 0-22], vitiligo [6·5 (0·7-12·2), n = 2, 0-20] and warts [2·9 (0-5·8), n = 4, 0-16]. Overall, the mean effect on QoL [weighted average CDLQI score 4·6 (95% CI 3·9-5·4)] for children with these conditions was small. However, many children were found to experience a very large impact on QoL (34% of children with atopic eczema, 10% with molluscum contagiosum and 1-5% with acne) in studies where the distributions of scores were provided.

CONCLUSIONS

Most skin conditions in children have a 'small' mean effect on QoL. However, the range is large and a significant proportion of children with many common skin conditions will experience a very large effect on quality of life.

摘要

背景

儿童皮肤病生活质量指数（CDLQI）是目前最广泛用于测量皮肤疾病对儿童生活质量（QoL）影响的工具。

目的

对一系列儿童皮肤病的所有已发表的 QoL 评分进行荟萃分析。

方法

通过检索 Medline 和 Embase 数据库，从 1995 年 1 月（CDLQI 创建）至 2014 年 12 月，对使用 CDLQI 问卷测量皮肤疾病 QoL 的研究进行了鉴定。研究根据疾病进行分组，采用荟萃分析对基线评分进行合并。

结果

共纳入 67 项符合条件的研究。对报告超过一次的疾病，总体估计的 CDLQI 评分为[点估计值（95%置信区间，CI），研究数量（n），评分范围]：特应性皮炎[8.5（7.1-9.8），n=38，0-29]、痤疮[5.3（1.9-8.5），n=5，0-30]、脱发[3.1（0-7.7），n=2，0-6]、传染性软疣[3.5（0.6-6.7），n=5，0-27]、银屑病[8.0（3.9-12.1），n=6，0-29]、疥疮[9.2（0.0-20.3），n=2，1-26]、荨麻疹[7.1（0-15.4），n=2，0-22]、白癜风[6.5（0.7-12.2），n=2，0-20]和疣[2.9（0-5.8），n=4，0-16]。总体而言，这些疾病对儿童 QoL 的平均影响[加权平均 CDLQI 评分 4.6（95%CI 3.9-5.4）]较小。然而，在提供评分分布的研究中，发现许多儿童的 QoL 受到很大影响（34%的特应性皮炎患儿，10%的传染性软疣患儿和 1-5%的痤疮患儿）。