Zhu Catherine K, Benharira Noha, Prosty Connor, Gabrielli Sofianne, Le Michelle, Netchiporouk Elena, Zhang Xun, Fein Michael N, Miedzybrodzki Barbara, Ben-Shoshan Moshe
Faculty of Medicine and Health Sciences, McGill University, Montreal, Québec, Canada.
Division of Dermatology, McGill University Health Centre, Montreal, Québec, Canada.
Int Arch Allergy Immunol. 2025 May 19:1-10. doi: 10.1159/000546466.
Chronic urticaria (CU) negatively impacts children's quality of life (QoL), yet data on pediatric CU remain limited. This study assessed CU's impact on QoL using the Children's Dermatology Life Quality Index (CDLQI).
Children (4-16 years) with CU were recruited and completed standardized questionnaires on demographics, CU type, management, and comorbidities. Chart review assessed laboratory data. Patients also completed the Urticaria Control Test (UCT), Urticaria Activity Score over 7 days (UAS7), and CDLQI at study entry. Multivariable logistic regression identified factors associated with clinically poor QoL.
Seventy-four children (median age = 10) were recruited: 39 (52.7%) had chronic spontaneous urticaria, 21 (27.0%) had chronic inducible urticaria, and 14 (16.2%) had both. Most children (n = 54; 72.9%) reported a clinically satisfactory (CDLQI ≤5), while 20 (27.0%) reported a clinically poor QoL (CDLQI >5). Factors associated with clinically poor QoL included older age at symptom onset (aOR = 1.04; 95% CI = 1.01-1.05), elevated C-reactive protein (CRP >5 mg/L) (aOR = 1.49; 95% CI = 1.04-2.13), and history of atopic dermatitis (aOR = 1.59; 95% CI = 1.18-2.13). In younger children (aged 4-10), cold urticaria was associated with clinically poor QoL (aOR = 1.44; 95% CI = 1.07, 2.00).
Older age at symptom onset, elevated CRP, atopic dermatitis, and cold urticaria are associated with clinically poor QoL in children with CU. These findings highlight the need for targeted interventions, such as psychosocial support and education, to improve patient outcomes.
慢性荨麻疹（CU）对儿童的生活质量（QoL）产生负面影响，但有关儿童CU的数据仍然有限。本研究使用儿童皮肤病生活质量指数（CDLQI）评估了CU对生活质量的影响。
招募患有CU的儿童（4至16岁），并让他们填写关于人口统计学、CU类型、治疗和合并症的标准化问卷。通过查阅病历评估实验室数据。患者在研究开始时还完成了荨麻疹控制测试（UCT）、7天荨麻疹活动评分（UAS7）和CDLQI。多变量逻辑回归确定了与临床生活质量差相关的因素。
招募了74名儿童（中位年龄 = 10岁）：39名（52.7%）患有慢性自发性荨麻疹，21名（27.0%）患有慢性诱导性荨麻疹，14名（16.2%）两者都有。大多数儿童（n = 54；72.9%）报告临床状况令人满意（CDLQI≤5），而20名（27.0%）报告临床生活质量差（CDLQI>5）。与临床生活质量差相关的因素包括症状发作时年龄较大（调整后比值比[aOR]=1.04；95%置信区间[CI]=1.01-1.05）、C反应蛋白升高（CRP>5mg/L）（aOR = 1.49；95%CI = 1.04-2.13）和特应性皮炎病史（aOR = 1.59；95%CI = 1.18-2.13）。在年幼儿童（4至10岁）中，寒冷性荨麻疹与临床生活质量差相关（aOR = 1.44；95%CI = 1.07，2.00）。
症状发作时年龄较大、CRP升高、特应性皮炎和寒冷性荨麻疹与CU儿童的临床生活质量差相关。这些发现凸显了采取针对性干预措施（如心理社会支持和教育）以改善患者预后的必要性。
