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[弓形虫病与皮肌炎:因果关系还是偶然关系?]

[Toxoplasmosis and dermatomyositis: a causal or casual relationship?].

作者信息

Lapetina F

机构信息

Divisione Pediatrica, USSL 50-52, Viadana (Mantova), Italia.

出版信息

Pediatr Med Chir. 1989 Mar-Apr;11(2):197-203.

PMID:2668906
Abstract

A case of a 10 year old girl with typical clinical, cutaneous and muscular picture of dermatomyositis and positive serological investigation for toxoplasmosis with neurological complications (hemiparesis and headache) is reported. In literature several case reports have suggested an association between acquired toxoplasmosis and polymyositis-dermatomyositis. A review of previous examples of this association is presented and the possible relationships between the disease are discussed. Although a certain causal relationship is not always established, we suggest that patients with active polymyositis or dermatomyositis should be studied serologically for toxoplasmosis, especially if steroid or immunosuppressive therapy is contemplated. We underline the importance, in these cases, of appropriate antiprotozoal therapy, that, in our experience and in most data reported in other cases, produces clinical benefit.

摘要

报告了一例10岁女孩,具有皮肌炎典型的临床、皮肤和肌肉表现,弓形虫血清学检查呈阳性,并伴有神经并发症(偏瘫和头痛)。文献中有几例病例报告提示获得性弓形虫病与多发性肌炎-皮肌炎之间存在关联。本文回顾了此前这种关联的实例,并讨论了疾病之间可能的关系。虽然并非总能确定某种因果关系,但我们建议,对于活动性多发性肌炎或皮肌炎患者,应进行弓形虫病血清学检查,尤其是考虑使用类固醇或免疫抑制疗法时。我们强调,在这些病例中,适当的抗原虫治疗很重要,根据我们的经验以及其他病例报告中的多数数据,这种治疗可产生临床疗效。

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