Di Piero G, Bellisario G, Di Maggio M, Garibaldi G, Isola M L, Pauselli F, Proia R
Aggiornamento della Relazione alle II Giornate Pediatriche Romane, Italia.
Pediatr Med Chir. 1989 Mar-Apr;11(2):209-17.
The number of cases of Kawasaki disease increases in Japan. The aetiology is still unknown but epidemiological studies suggest an infectious aetiology in spite that no specific microorganism has been implicated; it must be, probably present a hereditary predisposition connected with HLA subtypes. Many investigators reported an increase in the antibody level against several agents, among which bacteria and virus. Recently they found that aberrant regulation of T- and B-cells functions was associated with initiation of such antibody production, that in the majority of cases is self-limiting. The effectiveness of high- and low-doses of salicylates, given always associated with steroids, only up to fifteen days of illness, and Intravenous Gamma Globulin (IVGG), is also discussed.
日本川崎病的病例数有所增加。病因仍不明，但流行病学研究表明尽管尚未明确具体的微生物，但病因可能具有传染性；很可能存在与HLA亚型相关的遗传易感性。许多研究人员报告称针对多种病原体（包括细菌和病毒）的抗体水平有所升高。最近他们发现T细胞和B细胞功能的异常调节与此类抗体产生的起始有关，而在大多数情况下这种疾病是自限性的。文中还讨论了高剂量和低剂量水杨酸盐（始终与类固醇联合使用，仅在发病15天内使用）以及静脉注射丙种球蛋白（IVGG）的疗效。
