在临床3T扫描仪上对非人灵长类动物大脑进行扩散磁共振成像时的伪影校正
Artifact correction in diffusion MRI of non-human primate brains on a clinical 3T scanner.
作者信息
Zhang Xiaodong, Kirsch John E, Zhong Xiaodong
机构信息
Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
出版信息
J Med Primatol. 2016 Feb;45(1):21-7. doi: 10.1111/jmp.12204. Epub 2015 Dec 22.
BACKGROUND
Smearing artifacts were observed and investigated in diffusion tensor imaging (DTI) studies of macaque monkeys on a clinical whole-body 3T scanner.
METHODS
Four adult macaques were utilized to evaluate DTI artifacts. DTI images were acquired with a single-shot echo-planar imaging (EPI) sequence using a parallel imaging technique.
RESULTS
The smearing artifacts observed on the diffusion-weighted images and fractional anisotropy maps were caused by the incomplete fat suppression due to the irregular macaque frontal skull geometry and anatomy. The artifact can be reduced substantially using a novel three-dimensional (3D) shimming procedure.
CONCLUSION
The smearing artifacts observed on diffusion weighted images and fractional anisotropy (FA) maps of macaque brains can be reduced substantially using a robust 3D shimming approach. The DTI protocol combined with the shimming procedure could be a robust approach to examine brain connectivity and white matter integrity of non-human primates using a conventional clinical setting.
背景
在一台临床全身3T扫描仪上对猕猴进行的扩散张量成像（DTI）研究中观察并研究了涂抹伪影。
方法
使用4只成年猕猴评估DTI伪影。采用并行成像技术，通过单次激发回波平面成像（EPI）序列采集DTI图像。
结果
在扩散加权图像和分数各向异性图上观察到的涂抹伪影是由猕猴不规则的额部颅骨几何形状和解剖结构导致的脂肪抑制不完全引起的。使用一种新型的三维（3D）匀场程序可大幅减少该伪影。
结论
使用强大的3D匀场方法可大幅减少在猕猴脑扩散加权图像和分数各向异性（FA）图上观察到的涂抹伪影。结合匀场程序的DTI方案可能是一种在传统临床环境下检查非人类灵长类动物脑连接性和白质完整性的强大方法。
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