Department of Medical Imaging Center, the First Affiliated Hospital, Jinan University, Guangzhou, China.
Eur J Radiol. 2013 Sep;82(9):e476-83. doi: 10.1016/j.ejrad.2013.04.003. Epub 2013 Apr 29.
To assess the brain maturation of preterm infants using diffusion tensor imaging (DTI) and enhanced T2 star weighted angiography (ESWAN).
Conventional magnetic resonance imaging (MRI), DTI and ESWAN were performed in 60 preterm infants and 21 term controls. 60 preterm infants were subgrouped to two groups according to the age at imaging: before and at term-equivalent age (TEA). Fractional anisotropy (FA), apparent diffusion coefficient (ADC) map from DTI, T2 and R2 maps from ESWAN were post-processed at an off-line workstation. The values of FA, ADC, T2 and R2 from the posterior limb of internal capsule (PLIC), frontal white matter (FWM), occipital white matter (OWM) and lentiform nuclei (LN) were determined. These parameters were compared between preterm and term infants. Correlations of DTI and ESWAN parameters with the gestational age, postmenstrual age and postnatal age were analyzed.
ADCs of FWM, OWM and LN, and T2 values of the PLIC and LN were higher in the preterm infants at TEA compared with the term controls. The correlations were existed between the postmenstrual age and the values of FA, ADC, T2, R2 from the PLIC, values of ADC, T2, R2 from the LN, T2 value from the OWM. The correlations were also found between the postnatal age and the values of FA, ADC, T2 from the PLIC, and T2 value from the LN.
The maturity of preterm brain around TEA was different from that of term controls and appeared to be independent of the prematurity at birth. T2 was one of valuable indices to evaluate brain maturation in preterm infants.
使用弥散张量成像（DTI）和增强 T2*星加权血管造影（ESWAN）评估早产儿的脑成熟度。
对 60 例早产儿和 21 例足月对照者进行了常规磁共振成像（MRI）、DTI 和 ESWAN 检查。根据成像时的年龄（早产儿和胎龄相等时）将 60 例早产儿分为两组。在离线工作站上对 DTI 的各向异性分数（FA）、表观扩散系数（ADC）图，ESWAN 的 T2 和 R2 图进行后处理。测量内囊后肢（PLIC）、额白质（FWM）、枕白质（OWM）和豆状核（LN）的 FA、ADC、T2 和 R2 值。比较早产儿和足月儿之间的这些参数。分析 DTI 和 ESWAN 参数与胎龄、校正月龄和生后年龄的相关性。
TEA 时早产儿的 FWM、OWM 和 LN 的 ADC 值以及 PLIC 和 LN 的 T2 值均高于足月对照者。FA、ADC、PLIC 的 T2、R2 值，LN 的 ADC、T2、R2 值，OWM 的 T2 值与校正月龄之间存在相关性。PLIC 的 FA、ADC、T2 值和 LN 的 T2 值与生后年龄之间也存在相关性。
TEA 时早产儿脑的成熟度与足月对照者不同，且似乎与出生时的早产无关。T2 是评估早产儿脑成熟度的有价值指标之一。
Zotero 插件