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莱姆病相关性视神经视网膜炎——病例报告

Lyme disease associated neuroretinitis - Case report.

作者信息

Vanya Melinda, Fejes Imre, Jako Maria, Tula Areta, Terhes Gabriella, Janaky Marta, Bartfai Gyorgy

机构信息

Department of Obstetrics and Gynaecology, Faculty of Medicine, Albert Szent-Gyorgyi Clinical Centre, University of Szeged , Szeged , Hungary.

Department of Ophthalmology, Faculty of General Medicine, Albert Szent-Gyorgyi Clinical Centre University of Szeged , Szeged , Hungary.

出版信息

Acta Microbiol Immunol Hung. 2015 Dec;62(4):403-8. doi: 10.1556/030.62.2015.4.5.

Abstract

We describe a rare case of Lyme disease complicated by unilateral neuroretinitis in the right eye. We report a case of a 27-year-old woman with blurred vision on her right eye. Because of the suspicion of optic neuritis (multiplex sclerosis) neurological examination was ordered. Surprisingly, computer tomography of the brain revealed incomplete empty sella, which generally results not monocular, but bilateral optic nerve swelling. Opthalmological examination (ophthalmoscopy and optical coherence tomography) indicated not only monocular optic nerve, but retinal oedema next to the temporal part of the right optic disk. Visual evoked potentials (VEP) demonstrated no P100 latency delay and mild differences between the amplitudes of the responses of the left and right eye. Optical coherence tomography (OCT) demonstrated the swelling of the optic nerve head and oedematous retina at the temporal part of the disk. Suspicion of an inflammatory cause of visual disturbance blood tests was ordered. Doxycycline treatment was ordered till the result of the blood test arrived. The Western blot and ELISA test were positive for Borrelia burgdorferi sensu lato. Following one week corticosteroide and ceftriaxone treatments, the patient displayed a clinical improvement. Unilateral neuroretinitis with optic disk swelling due to neuroborreliosis is a rare complication and in many cases it is difficult to distinguish between inflammatory and ischemic lesions. Further difficulty in the diagnosis can occur when intracranial alterations such as empty sella is demonstrated by CT examination.

摘要

我们描述了一例罕见的莱姆病并发右眼单侧视神经视网膜炎的病例。我们报告了一名27岁女性,她右眼视力模糊。由于怀疑患有视神经炎(多发性硬化症),于是安排了神经学检查。令人惊讶的是,脑部计算机断层扫描显示蝶鞍空泡不完整,这通常不会导致单眼视神经肿胀,而是双眼视神经肿胀。眼科检查(检眼镜检查和光学相干断层扫描)不仅显示单眼视神经病变,还显示右侧视盘颞侧旁的视网膜水肿。视觉诱发电位(VEP)显示P100潜伏期无延迟,左右眼反应幅度存在轻微差异。光学相干断层扫描(OCT)显示视神经乳头肿胀以及视盘颞侧部分的视网膜水肿。由于怀疑视觉障碍的炎症原因,于是安排了血液检查。在血液检查结果出来之前,先进行了强力霉素治疗。免疫印迹法和酶联免疫吸附测定试验显示伯氏疏螺旋体广义种呈阳性。经过一周的皮质类固醇和头孢曲松治疗后,患者的临床症状有所改善。由神经型疏螺旋体病引起的伴有视盘肿胀的单侧视神经视网膜炎是一种罕见的并发症,在许多情况下,很难区分炎症性病变和缺血性病变。当CT检查显示颅内有诸如蝶鞍空泡等改变时,诊断会进一步困难。

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