白细胞介素-18与皮肤炎性疾病

Lee Ji Hyun, Cho Dae Ho, Park Hyun Jeong

Department of Dermatology, Seoul St Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul 137-701, Korea.

Department of Life Science, Sookmyung Women's University, Seoul 140-742, Korea.

Int J Mol Sci. 2015 Dec 9;16(12):29357-69. doi: 10.3390/ijms161226172.

Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

白细胞介素（IL）-18是一种IL-1家族细胞因子，是一种多效性免疫调节剂。IL-18通过诱导干扰素（IFN）-γ发挥强大的促炎作用。先前的研究表明IL-18与多种疾病的发病机制有关。然而，人们对IL-18在各种皮肤病中的生物学活性了解并不充分。在此，我们综述了IL-18在包括炎症性疾病在内的皮肤病中的表达和功能。本文为理解IL-18在皮肤病中的作用及其与疾病活动的关系提供了循证依据。