单次应用水解鱼胶原蛋白对人体皮肤模型中真皮蛋白表达和组织结构的影响。

Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models.

作者信息

Dondero Lorenzo, De Negri Atanasio Giulia, Lertora Erica, Tardanico Francesca, Demori Ilaria, Storace Pietro, Allaria Giorgia, Rispo Francesca, Robino Federica, Perata Elisabetta, Zanotti-Russo Matteo, Ferrando Sara, Grasselli Elena

机构信息

Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy.

Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Pisa, Italy.

出版信息

Sci Rep. 2025 Aug 11;15(1):29391. doi: 10.1038/s41598-025-11372-5.

DOI:10.1038/s41598-025-11372-5

PMID:40790128

Abstract

The use of collagen as an active ingredient in cosmetic products is becoming increasingly common. Recently, scientific interest has been focused on fish collagen, which is similar to human collagen and can be extracted from fish by-products. This study evaluates the cosmetic potential of Hydrolyzed Fish Collagen (HFC), testing it both as an aqueous solution (S-HFC) and as a formulation in cosmetic products (F-HFC) containing the same amount of HFC. The effects of S-HFC and F-HFC were evaluated on 2D (endothelial and keratinocyte cells) and 3D (EpiDerm and EpiDerm-FT) skin models. The results demonstrated that HFC, as an active ingredient, shows promising effects on skin physiology, including increased cell viability, enhanced wound healing, and an anti-wrinkle effect.

摘要

胶原蛋白作为化妆品中的活性成分使用正变得越来越普遍。最近，科学兴趣集中在鱼胶原蛋白上，它与人类胶原蛋白相似，并且可以从鱼类副产品中提取。本研究评估了水解鱼胶原蛋白（HFC）的美容潜力，将其作为水溶液（S-HFC）以及作为含有相同量HFC的化妆品配方（F-HFC）进行测试。在二维（内皮细胞和角质形成细胞）和三维（表皮模型和表皮-全层皮肤模型）皮肤模型上评估了S-HFC和F-HFC的效果。结果表明，HFC作为一种活性成分，对皮肤生理显示出有前景的效果，包括提高细胞活力、促进伤口愈合以及抗皱效果。