Ito Maiko, Shien Tadahiko, Kaji Mitsumasa, Mizoo Taeko, Iwamoto Takayuki, Nogami Tomohiro, Motoki Takayuki, Taira Naruto, Doihara Hiroyoshi, Miyoshi Shinichiro
Department of General Thoracic Surgery and Breast and Endocrine Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,
Acta Med Okayama. 2015;69(6):333-8. doi: 10.18926/AMO/53907.
We evaluated the usefulness of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) examinations to predict the pathological features in primary breast cancer. In particular, we evaluated the correlation between the maximum standardized uptake values (SUVmax) obtained by 18F-FDG PET/CT and the Ki67 expression in estrogen receptor (ER)-positive invasive ductal carcinoma (IDC). Primary IDC patients operated between March 2009 and July 2013 at Okayama University Hospital were enrolled. We evaluated the correlations between the SUVmax and age, postoperative pT, histological grade, lymph vascular invasion, status of hormone receptor, human epidermal growth factor receptor 2 (HER2), Ki67 expression and node status. The Ki67 expression was classified as high (＞ 14%) versus low (< 14%). We enrolled 138 patients with IDC. Their median SUVmax was 3.85 (range:0-52.57). In a univariate analysis, the SUVmax was significantly related to age, pT, histological grade, lymphovascular invasion, hormone receptor status, HER2 status, node status and Ki67. In the 113 patients with ER-positive IDC, there was a significant correlation between Ki67 and SUVmax (p ＝ 0.0030). The preoperative 18F-FDG PET/CT results of IDC patients had significant relationships with pathological status parameters. The determination of the preoperative SUVmax might help classify Luminal A and Luminal B patients among luminal-type breast cancer patients.
我们评估了术前18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）检查对预测原发性乳腺癌病理特征的有效性。特别是，我们评估了18F-FDG PET/CT获得的最大标准化摄取值（SUVmax）与雌激素受体（ER）阳性浸润性导管癌（IDC）中Ki67表达之间的相关性。纳入了2009年3月至2013年7月在冈山大学医院接受手术的原发性IDC患者。我们评估了SUVmax与年龄、术后pT、组织学分级、淋巴管侵犯、激素受体状态、人表皮生长因子受体2（HER2）、Ki67表达和淋巴结状态之间的相关性。Ki67表达分为高（＞14%）和低（＜14%）。我们纳入了138例IDC患者。他们的SUVmax中位数为3.85（范围：0-52.57）。在单因素分析中，SUVmax与年龄、pT、组织学分级、淋巴管侵犯、激素受体状态、HER2状态、淋巴结状态和Ki67显著相关。在113例ER阳性IDC患者中，Ki67与SUVmax之间存在显著相关性（p ＝ 0.0030）。IDC患者术前18F-FDG PET/CT结果与病理状态参数有显著关系。术前SUVmax的测定可能有助于在管腔型乳腺癌患者中区分Luminal A和Luminal B患者。
