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门诊儿科人群中丙氨酸转氨酶、血清甘油三酯、体重指数与非酒精性脂肪性肝病的关系

Relationships Between Alanine Aminotransferase, Serum Triglycerides, Body Mass Index and Nonalcoholic Fatty Liver Disease in an Outpatient Pediatric Clinic Population.

作者信息

Cohen Deborah, Gonzales-Pacheco Diana, Myers Orrin

机构信息

University of New Mexico, College of Education, Albuquerque, NM.

Clinical and Translational Science Center, University of New Mexico Health Sciences Center, Albuquerque, NM.

出版信息

J Pediatr Nurs. 2016 Mar-Apr;31(2):152-8. doi: 10.1016/j.pedn.2015.10.009. Epub 2015 Dec 11.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in children and adolescents. The goal of this study was to describe the demographic, anthropometric and biochemical data of children and adolescents diagnosed with NAFLD during a seven-year period in an outpatient pediatric clinic in the Southwest region of the US and to evaluate relationships between race, BMI, ALT, triglyceride levels, age and gender with a diagnosis of NAFLD. A retrospective medical record review of patients who attended an outpatient pediatric clinic with a billing diagnosis ICD-9 code of 571.8 was conducted. Forty-one patients met these criteria. The majority was male (74%) Hispanic (32%), Hispanic/Latino (68%) and obese. The small number of patients diagnosed with NAFLD in our study is consistent with previously reported results. Our results indicate that the population of this culturally diverse, high-risk population has significant clinical markers that are indicative of NAFLD.

摘要

非酒精性脂肪性肝病(NAFLD)是儿童和青少年中最常见的慢性肝病。本研究的目的是描述在美国西南部地区一家门诊儿科诊所七年间被诊断为NAFLD的儿童和青少年的人口统计学、人体测量学和生化数据,并评估种族、体重指数(BMI)、丙氨酸转氨酶(ALT)、甘油三酯水平、年龄和性别与NAFLD诊断之间的关系。对就诊于门诊儿科诊所且账单诊断ICD-9编码为571.8的患者进行了回顾性病历审查。41名患者符合这些标准。大多数为男性(74%),西班牙裔(32%)、西班牙裔/拉丁裔(68%)且肥胖。我们研究中被诊断为NAFLD的患者数量较少,这与先前报道的结果一致。我们的结果表明,这个文化多元的高危人群具有显著的临床指标,提示患有NAFLD。

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