Department of Gastroenterology, First Affiliated Hospital of Xi 'an Medical University, Xi 'an, Shaanxi Province, China.
Physical Examination Department, First Affiliated Hospital of Xi 'an Medical University, Xi 'an, Shaanxi Province, China.
Ann Hepatol. 2018 January-February;17(1):85-91. doi: 10.5604/01.3001.0010.7538.
To investigate the association of adolescent obesity with nonalcoholic fatty liver disease (NAFLD) and related risk factors in Xi'an, China.
A total of 4141 adolescents (2,061 girls and 2,080 boys, mean age: 18.62 ± 0.66 years, age range 15-22 years) were enrolled in this investigation. Anthropometric index was measured, and liver ultrasonography and liver function biochemical test were performed in all the subjects. T test, χ2 test and logistic regression analysis were used for statistical analyses.
The total rates of obesity was 7.9% (08/4,141). The prevalence rate of NAFLD was 8.1% (335/4141) with a declining trend from obesity, overweight to normal BMI. NAFLD prevalence rate in obese boys was significantly higher than in girls (χ2 = 56.5, P < 0.01). BMI, body weight, ALT, and AST in NAFLD group were higher than in non-NAFLD group (P < 0.05). The tangent point of ALT was 36 U/L using Youden index in boys, and 33 U/L in girls.
The prevalence of obesity and NAFLD in adolescents is higher in Xi'an than anticipated. Body weight and BMI may be the associated independent risk factors of NAFLD.
探讨中国西安青少年肥胖与非酒精性脂肪性肝病（NAFLD）及相关危险因素的关系。
共纳入 4141 名青少年（女生 2061 名，男生 2080 名，平均年龄 18.62±0.66 岁，年龄范围 15-22 岁）参与本研究。对所有研究对象进行体格检查、肝脏超声检查和肝功能生化检测。采用 t 检验、χ2 检验和 logistic 回归分析进行统计学分析。
肥胖总检出率为 7.9%（08/4141）。NAFLD 检出率为 8.1%（335/4141），且随着 BMI 由肥胖、超重逐渐向正常范围转变，NAFLD 的检出率逐渐下降。肥胖组男生的 NAFLD 检出率显著高于女生（χ2=56.5，P<0.01）。NAFLD 组的 BMI、体重、ALT 和 AST 均高于非 NAFLD 组（P<0.05）。使用 Youden 指数得出男生中 ALT 的切点为 36 U/L，女生为 33 U/L。
西安青少年肥胖和 NAFLD 的患病率高于预期。体重和 BMI 可能是非酒精性脂肪性肝病的相关独立危险因素。
