Wang Long, Guo Jinghui, Lu Jianping
Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Health Examination Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Oncotarget. 2016 Jun 14;7(24):35632-35642. doi: 10.18632/oncotarget.9691.
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and correlated with obesity. To evaluate the role of body mass index (BMI) and gender difference in NAFLD, 8817 general adult subjects underwent physical examinations and were divided into four groups: underweight, normal, overweight and obese. The risk factor compositions for NAFLD were evaluated in each group by gender. The percentage of subjects with NAFLD increased sharply from 0.4% in the underweight group up to 81.9 % in the obese group. BMI stratification showed distinct risk factor compositions associated with NAFLD in males and females according to BMI and improved the performance of NAFLD prediction models in each group. Triglycerides (TG), alanine transaminase (ALT), aspartate transaminase (AST), and uric acid were steady risk factors for NAFLD in males. Total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), ALT, and uric acid were steady risk factors for NAFLD in females. TG, ALT and uric acid were common risk factors in both genders with high performance for NAFLD discrimination. Our data provide gender- and BMI-specific risk factor compositions that will facilitate individualised treatment and benefit NAFLD control and prevention.
非酒精性脂肪性肝病（NAFLD）非常普遍，且与肥胖相关。为了评估体重指数（BMI）和性别差异在NAFLD中的作用，8817名成年普通受试者接受了体格检查，并被分为四组：体重过轻、正常、超重和肥胖。按性别对每组中NAFLD的危险因素构成进行了评估。NAFLD受试者的百分比从体重过轻组的0.4%急剧上升至肥胖组的81.9%。BMI分层显示，根据BMI，男性和女性与NAFLD相关的危险因素构成不同，且改善了每组中NAFLD预测模型的性能。甘油三酯（TG）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和尿酸是男性NAFLD的稳定危险因素。总胆固醇（TC）、TG、低密度脂蛋白胆固醇（LDL-C）、ALT和尿酸是女性NAFLD的稳定危险因素。TG、ALT和尿酸是两性中对NAFLD鉴别具有高效能的常见危险因素。我们的数据提供了按性别和BMI区分的危险因素构成，这将有助于个体化治疗，并有利于NAFLD的控制和预防。
