由酰肼、三氟乙醛甲基半缩醛、烯丙基溴和锡一锅法制备三氟甲基化高烯丙基N-酰基肼或α-亚甲基-γ-内酰胺。
One-pot preparation of trifluoromethylated homoallylic N-acylhydrazines or α-methylene-γ-lactams from acylhydrazines, trifluoroacetaldehyde methyl hemiacetal, allyl bromide and tin.
作者信息
Du Ganggang, Huang Danfeng, Wang Ke-Hu, Chen Xiaowei, Xu Yanli, Ma Junyan, Su Yingpeng, Fu Ying, Hu Yulai
机构信息
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China.
出版信息
Org Biomol Chem. 2016 Jan 28;14(4):1492-500. doi: 10.1039/c5ob02260f. Epub 2015 Dec 22.
An efficient and convenient one-pot method for the preparation of trifluoromethylated homoallylic N-acylhydrazines or α-methylene-γ-lactams has been described. In this process, allyl bromide and metal tin are used instead of toxic stannanes, and commercially available aqueous trifluoroacetaldehyde methyl hemiacetal was used as a trifluoromethyl source.
已经描述了一种高效便捷的一锅法制备三氟甲基化高烯丙基N-酰基肼或α-亚甲基-γ-内酰胺的方法。在此过程中，使用烯丙基溴和金属锡代替有毒的锡烷，并使用市售的三氟乙醛甲基半缩醛水溶液作为三氟甲基源。
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