Yan Honggai, Li Jun, Yang Liu
Department of Ophthalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100034, China.
Department of Ophthalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100034, China; Email:
Zhonghua Yan Ke Za Zhi. 2015 Oct;51(10):790-4.
Uveitis is an inflammatory disease which involves the uvea, retina, retinal vessel and vitreous body. The disease mainly affects middle age and young people with a variety of clinical manifestations and is often recurrent. If not treated properly, it will cause visual impairment and even blindness. Spectral domain optical coherence tomography (SD-OCT) is a noninvasive examination which provides clear images quickly without contacting the eyes. As the development of OCT, we can obtain the sectional images with similar resolution as histological examination. Especially, when the enhanced depth image OCT (EDI-OCT) was used in clinical, the structures of choroid could also be detected. Therefore, OCT was used more and more in uveitis patients. Anterior segment OCT (AS-OCT) is used to evaluate the inflammation in anterior chamber. It also can provide the changes of iris and corneal structures during acute phase and recovery period. SD-OCT can clearly display many kinds of retinopathy in patients with uveitis including macular edema and the changes of retinal thickness. EDI-OCT can be used to observe the changes of retina and choroid at the same time. In particular, the measurement of choroidal thickness can be used to evaluate the choroidal changes and the degree of the response to treatment. Therefore, SD-OCT helps to diagnose uveitis and is easily used in the disease follow-up and treatment effect observation.
葡萄膜炎是一种累及葡萄膜、视网膜、视网膜血管和玻璃体的炎症性疾病。该疾病主要影响中青年,有多种临床表现且常复发。若治疗不当,会导致视力损害甚至失明。光谱域光学相干断层扫描(SD-OCT)是一种非侵入性检查,无需接触眼睛就能快速提供清晰图像。随着OCT的发展,我们能够获得与组织学检查分辨率相似的断层图像。特别是,当增强深度成像OCT(EDI-OCT)应用于临床时,脉络膜结构也能被检测到。因此,OCT在葡萄膜炎患者中的应用越来越多。眼前节OCT(AS-OCT)用于评估前房炎症。它还能提供急性期和恢复期虹膜及角膜结构的变化。SD-OCT能清晰显示葡萄膜炎患者的多种视网膜病变,包括黄斑水肿和视网膜厚度变化。EDI-OCT可同时观察视网膜和脉络膜的变化。特别是,脉络膜厚度测量可用于评估脉络膜变化及治疗反应程度。因此,SD-OCT有助于诊断葡萄膜炎,且易于用于疾病随访和治疗效果观察。