Yurtkuran M, Dilek K, Güllülü M, Yavuz M, Müftüglu A
Department of Nephrology and Dialysis, Uludag University Medical School, Bursa, Turkey.
Angiology. 1989 Sep;40(9):791-4. doi: 10.1177/000331978904000903.
Effects of sublingual administration of nifedipine on systemic arterial pressure (BP), plasma renin activity (PRA), aldosterone level (AL), and serum sodium (Na) and potassium (K) levels, have been determined. A significant decrease was observed in systolic and diastolic blood pressure five minutes after the sublingual administration of nifedipine in 21 patients with mild or moderate essential hypertension. Furthermore, in an observation period of six hours, it was also established that the effect of nifedipine on systolic and diastolic blood pressure continued. An increase was observed in glomerular filtration rate, whereas there were no changes in PRA, AL, or serum Na and K levels.
已测定舌下含服硝苯地平对全身动脉压（BP）、血浆肾素活性（PRA）、醛固酮水平（AL）以及血清钠（Na）和钾（K）水平的影响。在21例轻度或中度原发性高血压患者中，舌下含服硝苯地平5分钟后，收缩压和舒张压显著下降。此外，在6小时的观察期内，还证实硝苯地平对收缩压和舒张压的作用持续存在。肾小球滤过率升高，而PRA、AL或血清Na和K水平无变化。
