Roychowdhury D, Padhy A K, Tiwari S C, Gupta K, Gopinath P G, Malhotra K K
Department of Nuclear Medicine, All-India Institute of Medical Sciences, New Delhi.
Indian J Physiol Pharmacol. 1988 Oct-Dec;32(4):278-84.
A prospective study was conducted in 25 patients with essential hypertension to study the effects of sublingual administration of nifedipine on some renal functions. Glomerular filtration rate was estimated by radioisotope clearance techniques using Tc-99m diethylene triamine pentaacetic acid (DTPA). The change in urinary excretion of sodium and uric acid were also monitored. A basal estimation of these parameters was followed by repeat studies after lowering the blood pressure to normotensive levels by sublingual administration of nifedipine. It was observed that acute administration of nifedipine does not produce a significant change in the glomerular filtration rate, but causes marked and significant natriuresis and uricosuria.
对25例原发性高血压患者进行了一项前瞻性研究，以探讨舌下含服硝苯地平对某些肾功能的影响。采用放射性核素清除技术，使用锝-99m二乙三胺五乙酸（DTPA）估算肾小球滤过率。同时监测尿钠和尿酸排泄的变化。在通过舌下含服硝苯地平将血压降至正常水平后，重复研究这些参数，并进行基础评估。结果发现，急性给予硝苯地平不会使肾小球滤过率发生显著变化，但会导致明显且显著的利钠和尿酸尿。
