Dolganiuc Angela
Department of Medicine/Gastroenterology, Hepatology, and Nutrition at the University of Florida, Gainesville, Florida.
Alcohol Res. 2015;37(2):299-309.
Both alcohol abuse and infection with hepatitis viruses can lead to liver disease, including chronic hepatitis. Alcohol and hepatitis viruses have synergistic effects in the development of liver disease. Some of these involve the cellular membranes and particularly their functionally active domains, termed lipid rafts, which contain many proteins with essential roles in signaling and other processes. These lipid rafts play a central role in the lifecycles of hepatitis viruses. Alcohol's actions at the lipid rafts may contribute to the synergistic harmful effects of alcohol and hepatitis viruses on the liver and the pathogenesis of liver disease.
酗酒和感染肝炎病毒均可导致肝脏疾病，包括慢性肝炎。酒精和肝炎病毒在肝脏疾病的发展过程中具有协同作用。其中一些作用涉及细胞膜，特别是其功能活跃区域，即脂筏，脂筏含有许多在信号传导和其他过程中起重要作用的蛋白质。这些脂筏在肝炎病毒的生命周期中起着核心作用。酒精在脂筏上的作用可能导致酒精和肝炎病毒对肝脏产生协同有害影响以及肝脏疾病的发病机制。
